Interleukin-4, Plasma

CPT: 83520
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Test Details

Synonyms

  • IL-4
  • IL4

Use

Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T lymphocytes, CD3+ cells, NK-T cells, mast cells, eosinophils, and basophils.1 IL-4 has multiple immune response modulation functions on a variety of cell types. It is an important regulator of isotype switching, inducing IgE production in B lymphocytes. It is an important modulator of the differentiation of precursor T helper cells to the TH2 subset that mediates humoral immunity and modulates antibody production. In addition, IL-4 has also been shown to have antitumor activity both in vivo and in vitro.1

Limitations

Results of this test are for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

Methodology

Enzyme-linked immunosorbent assay (ELISA)

Specimen Requirements

Specimen

Plasma

Volume

0.5 mL

Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)

Container

Lavender-top (EDTA) tube

Collection

Separate plasma from cells. Transfer plasma to a plastic transport tube.

Storage Instructions

Refrigerate; stable for 14 days. Stable at room temperature or frozen for 14 days. Freeze/thaw cycles x3.

Causes for Rejection

Gross hemolysis; sample left on cells

Clinical Information

Footnotes

1. Okada H, Banchereau J, Lotze MT, "Interleukin-4," Cytokine Handbook, Thomson AW, Lotze MT eds, Volume 1, 4th ed, London, UK and San Diego, CA: Academic Press, Elsevier Science, 2003, 227-62.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
140814 Interleukin-4, Plasma 27161-9 140815 Interleukin-4, Plasma pg/mL 27161-9

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