Synonyms
- IL-2
- IL2
Expected Turnaround Time
4 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
Specimen Requirements
Specimen
Plasma
Volume
0.5 mL
Minimum Volume
0.3 mL (Note: This volume does not allow for repeat testing.)
Container
Lavender-top (EDTA) tube
Collection
Separate plasma from cells. Transfer plasma to a plastic transport tube.
Storage Instructions
Refrigerate; stable for 14 days. Stable at room temperature or frozen for 14 days. Freeze/thaw cycles x3.
Causes for Rejection
Gross hemolysis; gross lipemia
Test Details
Use
Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or antigen-activated T lymphocytes.1 IL-2 plays a role in promoting the clonal expansion of antigen-specific cytotoxic and suppressor T cells. In vitro studies suggest that IL-2 may also be produced by dendritic cells and certain lymphoma cell lines.1 In addition, IL-2 has been shown to mediate multiple immune responses on a variety of cell types. IL-2 stimulates the proliferation of thymocytes; stimulates the proliferation and differentiation of activated B cells; promotes the growth, differentiation, and cytocidal activity of monocytes; induces the growth of natural killer cells and stimulates cytokine production by these cells, as well as enhancing the cytolytic activity of these cells; enhances the production of lymphocyte-activated killer (LAK) cells; and induces the proliferation and differentiation of oligodendrocytes.1
Limitations
Results of this test are for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.
Methodology
Enzyme-linked immunosorbent assay (ELISA)
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 140812 | Interleukin-2, Plasma | 33939-0 | 140813 | Interleukin-2, Plasma | pg/mL | 33939-0 |
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