Centromere B; chromatin; dsDNA; Jo-1; ribosomal P; RNP; scl-70; Sjögren's A; Sjögren's B; Sm/RNP; Smith (Sm)
2 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
0.5 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
Hemolysis; lipemia; gross bacterial contamination; icterus
Detect antibodies associated with SLE and mixed connective tissue disease. Sm antibodies are highly specific for SLE. RNP antibodies are found with a variety of rheumatoid diseases. RNP, Sm, SS-A, SS-B, Scl-70, and Jo-1 are extractable nucleoprotein complexes found in the nucleus and/or cytoplasm of substrate cells. Autoantibodies to the ribosomal P protein represent a highly specific marker for the diagnosis of SLE, where they have been associated with certain clinical manifestations. The native protein SmRNP contains two different regions: Sm and RNP that are different regions of the same macromolecule. SmRNP is the best antigen for detection of antibodies to either Sm or RNP but cannot discriminate between the antibody specificities. Inclusion of SmRNP increases sensitivity while inclusion of Sm and RNP increases specificity.
Multiplex flow immunoassay
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|164920||ANA Comprehensive Plus Profile||096343||Anti-DNA (DS) Ab Qn||IU/mL||5130-0|
|164920||ANA Comprehensive Plus Profile||016354||RNP Antibodies||AI||29374-6|
|164920||ANA Comprehensive Plus Profile||016362||Smith Antibodies||AI||11090-8|
|164920||ANA Comprehensive Plus Profile||016376||Smith/RNP Antibodies||AI||27048-8|
|164920||ANA Comprehensive Plus Profile||018707||Antiscleroderma-70 Antibodies||AI||27416-7|
|164920||ANA Comprehensive Plus Profile||012684||Sjogren's Anti-SS-A||AI||17792-3|
|164920||ANA Comprehensive Plus Profile||012692||Sjogren's Anti-SS-B||AI||17791-5|
|164920||ANA Comprehensive Plus Profile||012581||Antichromatin Antibodies||AI||51775-5|
|164920||ANA Comprehensive Plus Profile||012701||Antiribosomal P Antibodies||AI||13636-6|
|164920||ANA Comprehensive Plus Profile||161457||Anti-Jo-1||AI||11565-9|
|164920||ANA Comprehensive Plus Profile||164816||Anti-Centromere B Antibodies||AI||53982-5|
|164920||ANA Comprehensive Plus Profile||164879||See below:||N/A|
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