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Myeloproliferative Neoplasms With Hypereosinophilia (MPN/HES), FISH

CPT: Contact CPT coding department at 800-222-7566, ext 6-8400.
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Synonyms

  • Chronic Myeloid Neoplasm
  • Hypereosinophilic Syndrome
  • Leukemia/Lymphoma-specific FISH
  • Myeloproliferative Neoplasms

Test Includes

Fluorescence in situ hybridization (FISH) for myeloproliferative neoplasms with hypereosinophilia (MPN/HES) targeting rearrangement of FGFR1, PDGFRa, and PDGFRb.


Special Instructions

Indicate pertinent clinical diagnosis and previous cytogenetic studies on the test request form. Note: This test number is used for tracking FISH specimens to the testing laboratory. Bill codes will be added when testing is complete based on the processes performed in the laboratory. Call Customer Service (800-345-4363) for a list of applicable test codes.


Expected Turnaround Time

4 - 7 days



Related Documents


Specimen Requirements


Specimen

Blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slides with metaphase and/or interphase nuclei or bone marrow touch prep slides are acceptable for testing.


Volume

10 mL blood (adult), 5 mL blood (pediatric), 3 mL bone marrow, fixed-cell pellet from a cytogenetic analysis, 6 slides with metaphase and/or interphase nuclei or 6 touch prep slides


Minimum Volume

5 mL blood (adult), 1 mL blood (pediatric), 1 mL bone marrow, fixed-cell pellet from a cytogenetic analysis, 6 slides with metaphase and/or interphase nuclei, or 6 bone marrow touch prep slides (Note: This volume does not allow for repeat testing.)


Container

Green top (sodium heparin) tube: pediatric Vacutainer is optimal or lavender-top (EDTA) tube (suboptimal). Adjust tube size to sample volume to avoid heparin toxicity.


Collection

Transport to the testing lab at room temp is acceptable. Do not allow the sample to overheat or freeze. Use a cool pack or LabCorp transport kit if necessary. Specimens should optimally arrive in the laboratory within 48 hours of collection. Indicate date of collection on the test request form.


Storage Instructions

Maintain the specimen at either room temperature or refrigerate. Do not freeze.


Causes for Rejection

Broken Vacutainer, broken or stained slides; paraffin blocks; paraffin slides; decalcified bone cores; frozen specimen; quantity not sufficient for analysis


Test Details


Use

Leukemia/lymphoma monitoring of residual disease, transplants, and indolent clones.


Limitations

Molecular mutations below the resolution of FISH will not be detected. This test will not detect regions not targeted by FISH probes in this panel.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Fluorescence in situ hybridization (FISH)


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511444 MPN w/Hypereosinophilia FISH 511426 Specimen Type 31208-2
511444 MPN w/Hypereosinophilia FISH 511446 Cells Counted 62361-1
511444 MPN w/Hypereosinophilia FISH 511447 Cells Analyzed 62360-3
511444 MPN w/Hypereosinophilia FISH 511448 FISH Result 62356-1
511444 MPN w/Hypereosinophilia FISH 511449 Interpretation 62365-2
511444 MPN w/Hypereosinophilia FISH 511458 Director Review: 48672-0
511444 MPN w/Hypereosinophilia FISH 512123 PDF 51967-8

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