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Fluorescence in situ hybridization (FISH) for myeloproliferative neoplasms with hypereosinophilia (MPN/HES) targeting rearrangement of FGFR1, PDGFRa, and PDGFRb.
Indicate pertinent clinical diagnosis and previous cytogenetic studies on the test request form. Note: This test number is used for tracking FISH specimens to the testing laboratory. Bill codes will be added when testing is complete based on the processes performed in the laboratory. Call Customer Service (800-345-4363) for a list of applicable test codes.
4 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slides with metaphase and/or interphase nuclei or bone marrow touch prep slides are acceptable for testing.
10 mL blood (adult), 5 mL blood (pediatric), 3 mL bone marrow, fixed-cell pellet from a cytogenetic analysis, 6 slides with metaphase and/or interphase nuclei or 6 touch prep slides
5 mL blood (adult), 1 mL blood (pediatric), 1 mL bone marrow, fixed-cell pellet from a cytogenetic analysis, 6 slides with metaphase and/or interphase nuclei, or 6 bone marrow touch prep slides (Note: This volume does not allow for repeat testing.)
Green top (sodium heparin) tube: pediatric Vacutainer is optimal or lavender-top (EDTA) tube (suboptimal). Adjust tube size to sample volume to avoid heparin toxicity.
Transport to the testing lab at room temp is acceptable. Do not allow the sample to overheat or freeze. Use a cool pack or LabCorp transport kit if necessary. Specimens should optimally arrive in the laboratory within 48 hours of collection. Indicate date of collection on the test request form.
Maintain the specimen at either room temperature or refrigerate. Do not freeze.
Broken Vacutainer, broken or stained slides; paraffin blocks; paraffin slides; decalcified bone cores; frozen specimen; quantity not sufficient for analysis
Leukemia/lymphoma monitoring of residual disease, transplants, and indolent clones.
Molecular mutations below the resolution of FISH will not be detected. This test will not detect regions not targeted by FISH probes in this panel.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Fluorescence in situ hybridization (FISH)
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|511444||MPN w/Hypereosinophilia FISH||511426||Specimen Type||31208-2|
|511444||MPN w/Hypereosinophilia FISH||511446||Cells Counted||62361-1|
|511444||MPN w/Hypereosinophilia FISH||511447||Cells Analyzed||62360-3|
|511444||MPN w/Hypereosinophilia FISH||511448||FISH Result||62356-1|
|511444||MPN w/Hypereosinophilia FISH||511449||Interpretation||62365-2|
|511444||MPN w/Hypereosinophilia FISH||511458||Director Review:||48672-0|
|511444||MPN w/Hypereosinophilia FISH||512123||51967-8|
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