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IFNL3 (IL28B) Genotyping (rs12979860)

CPT: 81283
Updated on 01/29/2020
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Expected Turnaround Time

5 - 7 days

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Specimen Requirements


Whole blood or LabCorp buccal swab kit (buccal swab collection kit contains instructions for use of a buccal swab)


7 mL whole blood or LabCorp buccal swab kit

Minimum Volume

3 mL whole blood or two buccal swabs


Lavender-top (EDTA) tube, yellow-top (ACD) tube, or LabCorp buccal swab kit

Storage Instructions

Maintain specimen at room temperature or refrigerate at 4°C.

Causes for Rejection

Frozen specimen; hemolysis; quantity not sufficient; improper container; one buccal swab; wet buccal swab

Test Details


This assay is used for genotyping IL-28B rs12979860.


IL28B genotype should be interpreted in the context of other clinical factors. This assay detects only a single base change in the IL28B gene (single nucleotide polymorphism rs12979860 C/T). No other polymorphisms are detected by this assay. Rare sequence polymorphisms close to rs12979860 may interfere with the genotype results of this assay.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Real-time polymerase chain reaction (PCR) with allele-specific TaqMan® probes is used to detect a single nucleotide polymorphism (SNP) (rs12979860 C/T) on chromosome 19q13. The rs12979860 SNP maps 3 kilobases upstream of the IL28B gene (OMIM 607402), which encodes the type III interferon-λ3.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
480630 IFNL3 (IL28B) Genotyping 480631 IL28B Polymorphism Result: 60279-7
480630 IFNL3 (IL28B) Genotyping 480638 Methodology: 49549-9
480630 IFNL3 (IL28B) Genotyping 480637 Director Review: 72486-4

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