Familial Hypercholesterolemia (FH) Screen

CPT: 82465; 83718; 83721
Print Share


  • FH Screen
  • LDL and Non-HDLC FH Screen

Test Includes

Cholesterol, total; high-density lipoprotein (HDL) cholesterol; non-HDL cholesterol (calculation); LDL cholesterol direct

Expected Turnaround Time

Within 1 day

Related Documents

Specimen Requirements




2 mL

Minimum Volume

1 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube


Separate serum from cells within 45 minutes of venipuncture. Lipid profiles are best avoided following acute myocardial infarction, for up to three months, although cholesterol can be in the first 24 hours.

Storage Instructions

Maintain specimen at room temperature.

Patient Preparation

Patient should be on a stable diet, ideally for two to three weeks prior to collection of blood. Fasting is not necessary for this profile, however fasting for 12 to 14 hours prior to collection of the specimen is recommended where the triglyceride value provides a priori diagnostic information such as screening for familial hypercholesterolemia or early onset heart disease, pancreatitis, or confirming hypertriglyceridemia.

Causes for Rejection

Improperly labeled specimen

Test Details


The 2011 clinical guidance from the National Lipid Association Expert Panel1 recommends universal screening of children age 9 to 11 years and adults with a fasting lipid profile that include LDL cholesterol and/or non-HDL cholesterol for identification of patients at risk of familial hypercholesterolemia (FH). Cholesterol screening should be considered beginning at age two for children with a family history of premature cardiovascular disease or elevated cholesterol. All individuals should be screened by age 20. For all patients with LDL-C and/or non-HDL-C levels listed in the table above, a family history of high cholesterol and heart disease in first-degree relatives should be collected. The likelihood of FH is higher in individuals with a positive family history of hypercholesterolemia or of premature CHD (onset in men before age 55 years and women before age 65 years). Cascade screening of all first-degree relatives for lipid levels is considered the most cost-effective lifesaving procedure. Genetic screening for FH-associated mutations in LDL receptor, Apo B, and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes may be useful when the diagnosis is uncertain. The prevalence of FH in general population is reported to be 1 in 300 to 500 making FH among one of the most common serious genetic disorders. Some populations, such as French Canadian and Dutch Afrikaner, have a prevalence as high as 1 in 100.


See individual tests.

Reference Interval

See table.








FH should be suspected if at age:







FH should be strongly suspected (with approximate probability of 80%) if at age:











1. Goldberg AC, Hopkins PN, Toth PP, et al. Familial hypercholesterolemia: screening, diagnosis, and management of pediatric and adult patients clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. J Clin Lipidol. 2011; 5(3):133-140.21600517


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
368600 Familial Hypercholesterolemia 24331-1 001065 Cholesterol, Total mg/dL 2093-3
368600 Familial Hypercholesterolemia 24331-1 011817 HDL Cholesterol mg/dL 2085-9
368600 Familial Hypercholesterolemia 24331-1 011976 Non-HDL Cholesterol mg/dL 43396-1
368600 Familial Hypercholesterolemia 24331-1 120297 LDL Chol. (Direct) mg/dL 18262-6
368600 Familial Hypercholesterolemia 24331-1 011831 Comment: 77202-0

For Providers

Please login to order a test

Order a Test

© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf