Herpes Simplex Virus (HSV) Type 2-Specific Antibodies, IgG With Reflex to Supplemental Testing
Synonyms
- Herpes-2
- HSV Type 2-Specific Antibody, IgG
- HSV-2
Special Instructions
If patient result falls between 0.91 (Equivocal) and 5.00 (Low Positive) Index values, the specimen will reflex to 163006 HSV-2 Supplemental test per CDC guidelines.
If reflex test is performed, additional charges/CPT code(s) may apply.
Expected Turnaround Time
1 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
For more information, please view the literature below.
Testing Options to Support Diagnosis and Screening of Herpes Simplex Virus (HSV)
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube, gel-barrier tube, or serum transfer tube
Storage Instructions
Refrigerate
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 2 days |
Refrigerated | 7 days |
Frozen | 98 days |
Freeze/Thaw Cycle | Stable x4 |
Causes for Rejection
Hemolysis; lipemia; grossly icteric; visible particulate matter; gross bacterial contamination
Test Details
Use
Detect IgG antibodies specific to HSV type 2 infection; confirm or rule out possible infection with herpes simplex type 2 virus in prenatal patients in whom HSV 2 infection can cause serious prenatal disease. Per CDC guidelines, specimens with equivocal or low positive results for HSV-2 type specific IgG will reflex for supplemental testing by another assay.
In a patient with no history of lesion disease, a positive result for this test may be indicative that the primary infection was asymptomatic. The magnitude of the Index Value is not indicative of the amount of antibody present in the patient sample. Once infected by HSV, it is possible for a patient to shed virus without the development of lesions (asymptomatic shedding). This test does not indicate the site of HSV infection. There is a considerable homology between HSV-1 and HSV-2 antigens, so that antibodies formed against either virus are highly cross-reactive. This assay is based on glycoprotein G-2, purified from HSV-2 infected cells, and is specific for type 2 antibodies.
HSV-2 IgG Type Specific | HSV-2 IgG Supplemental | Interpretation |
|---|---|---|
Positive / Equivocal | Positive | Indicates the presence of detectable IgG antibodies to HSV-2. |
Positive / Equivocal | Negative | Unable to confirm the presence of IgG antibodies to HSV-2. Recommend retesting in 2 to 4 weeks. |
Limitations
This test is intended for qualitative determination only. The magnitude of the Index Value is not indicative of the amount of antibody present in the patient sample.
Methodology
Chemiluminescent immunoassay (CLIA). Reflex of specimens equivocal and low positive for HSV-2 type specific IgG to a membrane based immunoassay.
Additional Information
Set up Monday thru Friday.
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 163033 | HSV-2 Type Spec Ab, IgG w/Rflx | 5209-2 | 163034 | HSV 2 IgG, Type Spec | index | 5209-2 |
| Reflex Table for HSV 2 IgG, Type Spec | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 000000 | 163006 | 000000 | 163013 | HSV-2 IgG Supplemental Test | |
| Reflex 2 | 043180 | |||||
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