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This assay is not currently available in New York state.
Expected Turnaround Time
10 - 14 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Lavender-top (EDTA) tube, green-top (sodium heparin) tube
Collect 2-4 mL blood in sodium heparin (green-top) or EDTA (purple-top) tube.
Remove plasma and freeze at -20°C. Store frozen at -20°C and ship frozen.
Causes for Rejection
Aromatic L-amino acid decarboxylase (AADC) is a pyridoxal 5'-phosphate dependent enzyme responsible for the formation of dopamine and serotonin. AADC deficiency is a congenital autosomal recessive metabolic disorder that causes hypotonia, hypokinesia, oculogyric crises, and signs of autonomic dysfunction beginning in infancy. In AADC deficiency, L-dopa accumulates and can be methylated by catechol O-methyltransferase using S-adenosylmethionine as the methyl donor to form 3-O-methyldopa (3-OMD). 3-OMD is more stable than L-dopa and can be detected in blood.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|620176||3-O-Methyldopa Plasma||50141-1||230163||Specimen Status||N/A|