Diabetes Comorbidity Assessment

CPT: 80061; 82565; 82570; 82043
Updated on 12/3/2018
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Test Details

Use

This test is intended to help inform the clinician about the presence of hyperlipidemia as an index to cardiovascular disease and to identify patients with chronic kidney disease.

Limitations

LDL cholesterol cannot be calculated if triglyceride is >400 mg/dL.

Methodology

Lipid Profile With Non‐HDL Cholesterol: See individual tests.

Kidney Profile ‐ creatinine: kinetic jaffe. Albumin: immunoturbidimetric

Additional Information

The relationship between diabetes, cardiovascular disease, and chronic kidney disease is widely recognized. Among individuals with type 2 diabetes, cardiovascular disease is the leading cause of morbidity and mortality. Chronic kidney disease occurs in 20% to 40% of patients with diabetes and may be present at the time of diagnosis.

While not considered to be a clinical entity itself, individuals with prediabetes are at increased risk for diabetes and cardiovascular disease. Additionally, observational evidence has linked prediabetes with early nephropathy, chronic kidney disease, small fiber neuropathy, diabetic retinopathy, and increased risk of macrovascular disease.

Specimen Requirements

Specimen

Serum (preferred) or plasma and random urine

Volume

3 mL serum or plasma and 10 mL urine

Minimum Volume

1 mL serum or plasma and 2 mL urine

Container

Red-top tube, gel-barrier tube, green-top (heparin) tube, or lavender-top (EDTA) tube and plastic urine container

Patient Preparation

Patient should be on a stable diet, ideally for two to three weeks prior to collection of blood, and should fast for 12 to 14 hours before collection of the specimen.

Collection

Separate serum or plasma from cells within 45 minutes of collection. Lipid panels are best avoided for up to three months following acute myocardial infarction, although cholesterol can be measured in the first 24 hours.

Collect random urine without preservatives. pH must be 4 to 8.

Storage Instructions

Maintain specimens at room temperature.

Stability Requirements

Temperature

Period

Room temperature

3 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x2

Causes for Rejection

Specimen with greatly elevated triglycerides (>400 mg/dL); improper labeling; hemolysis

Clinical Information

Special Instructions

State patient's age and sex on the request form.

References

American Diabetes Association. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2018.Diabetes Care. 2018 Jan; 41(Suppl 1):S86-S104.29222380
Eckel RH, Kahn R, Robertson RM, Rizza RA. Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association. Circulation. 2006 Jun 27;113(25):2943-2946.16801475
Executive Summary of The Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. JAMA. 2001 May 16;285(19):2486-2497.11368702
Lamarche B, Tchernof A, Moorjani S, et al. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Québec Cardiovascular Study. Circulation. 1997 Jan 7;95(1):69-75.8994419
Ridker PM, Rifai N, Cook NR, Bradwin G, Buring JE. Non-HDL cholesterol, apolipoproteins A-1 and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA. 2005 Jul 20;294(3):326-333.16030277

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
023400 Diabetes Comorbidity Risk 001370 Creatinine mg/dL 2160-0
023400 Diabetes Comorbidity Risk 013672 Creatinine, Urine mg/dL 2161-8
023400 Diabetes Comorbidity Risk 140097 Albumin, Urine ug/mL 14957-5
023400 Diabetes Comorbidity Risk 140291 Alb/Creat Ratio mg/g creat 9318-7
023400 Diabetes Comorbidity Risk 001065 Cholesterol, Total mg/dL 2093-3
023400 Diabetes Comorbidity Risk 001172 Triglycerides mg/dL 2571-8
023400 Diabetes Comorbidity Risk 011817 HDL Cholesterol mg/dL 2085-9
023400 Diabetes Comorbidity Risk 011916 VLDL Cholesterol Cal mg/dL 13458-5
023400 Diabetes Comorbidity Risk 012054 LDL Cholesterol Calc mg/dL 13457-7
023400 Diabetes Comorbidity Risk 011976 Non-HDL Cholesterol mg/dL 43396-1
023400 Diabetes Comorbidity Risk 011824 Comment: 77202-0
023400 Diabetes Comorbidity Risk 100791 eGFR If NonAfricn Am mL/min/1.73 88284-4
023400 Diabetes Comorbidity Risk 100797 eGFR If Africn Am mL/min/1.73 88294-4

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf