Herpes Simplex Virus (HSV) Types 1 and 2-Specific Antibodies, IgG With Reflex to Supplemental HSV-2 Testing

CPT: 86695; 86696
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Synonyms

  • Herpes 1 and 2; HSV Types 1- and 2- Specific Antibodies, IgG; HSV-1 and HSV-2; HSV

Special Instructions

For 163034 HSV-2 IgG, Type Specific:If patient result falls between 0.91 (Equivocal) and 5.00 (Low Positive) Index Values, the specimen will reflex to 163006 HSV-6 Supplemental test per CDC guidelines.

If reflex test is performed, additional charges/CPT code(s) my apply.


Expected Turnaround Time

1 - 3 days


Related Documents

For more information, please view the literature below.

Genital Herpes Diagnosis: Technology and Test Options


Specimen Requirements


Specimen

Serum


Volume

1.5 mL


Minimum Volume

1 mL


Container

Red-top tube, gel-barrier tube, or serum transfer tube


Storage Instructions

Refrigerate


Stability Requirements

Temperature

Period

Room temperature

2 days

Refrigerated

7 days

Frozen

98 days

Freeze/Thaw Cycle

Stable x4


Causes for Rejection

Hemolysis; lipemia; grossly icteric; visible particulate matter; gross bacterial contamination


Test Details


Use

Detect IgG antibodies specific to HSV types 1 and/or 2 infection; confirm or rule out possible infection with herpes simplex types 1 and/or 2 virus in prenatal patients in whom HSV 2 infection can cause serious prenatal disease. Per CDC guidelines, specimens with equivocal or low positive results for HSV-2 type specific IgG will reflex for supplemental testing by another assay.

In a patient with no history of lesion disease, a positive result for this test may be indicative that the primary infection was asymptomatic. Once infected by HSV, it is possible for a patient to shed virus without the development of lesions (asymptomatic shedding). This test does not indicate the site of HSV infection. The magnitude of the Index Value is not indicative of the amount of antibody present in the patient sample. There is a considerable homology between HSV-1 and HSV-2 antigens, so that antibodies formed against either virus are highly cross-reactive. These assays are based on purified recombinant glycoprotein G-1 (HSV-1) or G-2 (HSV-2) antigens.

HSV-2 IgG Type Specific

HSV-2 IgG Supplemental

Interpretation

Positive / Equivocal

Positive

Indicates the presence of detectable IgG antibodies to HSV-2.

Positive / Equivocal

Negative

Unable to confirm the presence of IgG antibodies to HSV-2. Recommend retesting in 2 to 4 weeks.


Limitations

This test is intended for qualitative determination only. The magnitude of the Index Value is not indicative of the amount of antibody present in the patient sample.


Methodology

Chemiluminescent immunoassay (CLIA). Reflex of specimens equivocal and low positive for HSV-2 type specific IgG to a membrane based immunoassay.


Additional Information

Set up Monday thru Friday.


References

Ashley R, Cent A, Maggs V, Nahmias A, Corey L. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types 1 and 2. Ann Intern Med. 1991 Oct 1; 115(7):520-526.1652909
Centers for Disease Control and Prevention. Sexually-transmitted disease treatment guidelines 2002. MMWR. 2002; 51(RR-6).12184549
Corey L. The current trend in genital herpes. Progress in prevention. Sex Transm Dis. 1994 Mar-Apr; 21(2 Suppl):S38-S44.8042114
Whitley RJ. Herpes simplex infections of women and their offspring: Implications for a developed society. Proc Natl Acad Sci USA. 1994 Mar 29; 91(7):2441-2447 (review).8146137

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164922 HSV 1 and 2-Spec Ab, IgG w/Rfx 164903 HSV 1 IgG, Type Spec index 5206-8
164922 HSV 1 and 2-Spec Ab, IgG w/Rfx 163034 HSV 2 IgG, Type Spec index 5209-2
Reflex Table for HSV 2 IgG, Type Spec
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 163006 HSV-2 IgG Supplemental Test 163013 HSV-2 IgG Supplemental Test 43180-9

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