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- Microarray Oncology
- Reveal® SNP Array
High resolution detection of genomic imbalances that may be present in neoplastic clonal evolution; provides detection of copy-neutral loss of heterozygosity (acquired uniparental disomy) associated with cancer gene mutation. The microarray will detect DNA copy-number changes at a threshold >1 Mb for deletions, >2 Mb for duplications.
This assay does not detect balanced rearrangements and low level mosaicism, or tetraploidy.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Whole genome SNP copy number microarray analysis using Molecular Inversion Probe (MIP) technology optimized for highly degraded FFPE samples or degraded fixed cell pellets.
Formalin fixed paraffin embedded (FFPE) tissue; fixed cell pellets
One paraffin block or ten 10-micron thick section slides
Sufficient sample to obtain enough DNA to run microarray
FFPE specimen should be fixed in 10% neutral-buffered formalin or formaldehyde. Cell pellet should be fixed in 3:1 methanol:acetic acid.
Causes for Rejection
Improperly embedded preparation; decalcified bone or bone core
Pertinent medical findings should accompany the test request form. If prior FISH analysis has been performed, include copy of report. Please direct questions to genetic customer service at 800-345-4363.
This assay is not approved for patients of New York State physicians.