MHPG, 24-Hour Urine

TEST: 803193
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CPT: 82542
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Synonyms

  • 3-Methoxy-4-Hydroxyphenylglycol

Expected Turnaround Time

10 - 14 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Urine (24-hour)

Volume

10 mL

Minimum Volume

1.5 mL

Container

Plastic urine container without preservative

Collection

24-hour urine collection; submit an aliquot of the mixed 24-hour specimen and record total urine volume on test request form

Storage Instructions

Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.

Causes for Rejection

Urine from preservative tube

Test Details

Use

Monitor levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG), a metabolite of norepinephrine. Patients with either high or low levels of MHPG have demonstrated marked sleep disturbance, which may be related to unipolar depression.1

Methodology

High-pressure liquid chromatography with fluorescence detection (HPLC/FL)

Footnotes

1. Samson JA, Mirin SM, Griffin M, Borrelli D, Schildkraut JJ. Urinary MHPG and clinical symptoms in patients with unipolar depression. Psychiatry Res. 1994 Feb; 51(2):157-165. 8022950

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
803193 MHPG 24 Hour Urine 803194 Total Urine Volume ml/24hr 3167-4
803193 MHPG 24 Hour Urine 803195 MHPG, ng/ml ng/ml 21043-5
803193 MHPG 24 Hour Urine 791238 MHPG, 24 Hr Urine mg/24hr 9695-8

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