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- Histoplasma Galactomannan Antigen EIA
- Histoplasma Urinary Antigen
Diagnosis of histoplasmosis based upon detection of antigen
A negative result does not preclude a diagnosis of histoplasmosis. This assay has been documented to cross-react with Blastomyces dermatitidis, Coccidioides immitis, Paracoccidioides brasiliensis, and Penicillium marneffei. Positive tests should be confirmed in areas or patient groups where these organisms are endemic or a risk. The following substances may interfere with the assay results: foods which produce color in urine; vaginal cream; caffeine; ascorbic acid, itraconazole; amphotericin B; acetaminophen; and acetylsalicylic acid.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Enzyme immunoassay (EIA)
Normal value <0.50 ng/mL
Antigen detection may be useful in acute disease, especially in individuals also infected with HIV, who frequently have the disseminated form of histoplasmosis without detectable antibodies to the fungus. In chronic disease, antigen may not be detected due to the low fungal burden. The highest sensitivity for rapidly and accurately diagnosing histoplasmosis in patients with acute pulmonary or disseminated infection can be obtained by testing both urine and serum.
Collect specimen aseptically
Refrigerate. Store specimens at 2°C to 8°C or frozen at -16°C to 24°C for up to 14 days.
Causes for Rejection
Specimen not refrigerated or frozen; insufficient specimen volume; inappropriate specimen source; inappropriate specimen collection device (ie, urine collected/submitted in a maintenance fluid or a preservative such as boric acid); specimen stability exceeded; name discrepancy between the name on the specimen container and the name in the computer or on the requisition
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|183560||Histoplasma Gal'mannan Ag Ur||48952-6||183562||Histoplasma Gal'mannan Ag Ur||44524-7|
|183560||Histoplasma Gal'mannan Ag Ur||48952-6||164013||Disclaimer:||N/A|
|Reflex Table for Histoplasma Gal'mannan Ag Ur|
|Order Code||Order Name||Result Code||Result Name||UofM||Result LOINC|
|Reflex 1||183563||Histoplasma Gal'mannan Ag Qn U||183563||Histoplasma Gal'mannan Ag Qn U||ng/mL||48952-6|