Venous Thrombosis Profile (Esoterix)

CPT: 81240; 83090; 85240; 85300; 85303; 85306; 85307; 85598; 85613(x2); 85730; 85732(x2); 86146(x3); 86147(x2)
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Test Details

Test Includes

Activated partial thromboplastin time (aPTT); anticardiolipin antibodies IgG, IgM; antithrombin activity; β2-glycoprotein I, IgA, IgG, IgM; dilute Russell's viper venom time (dRVVT) confirm seconds; dilute Russell's viper venom time (dRVVT) ratio; dilute Russell's viper venom time (dRVVT) screen seconds; factor II gene mutation; factor VIII activity; hexagonal phospholipid neutralization; homocysteine; protein C activity (chromogenic); protein C resistance with factor V deficiency; protein S antigen, free

Methodology

See individual tests.

Specimen Requirements

Specimen

Serum, plasma, and whole blood

Volume

Three 2-mL platelet-poor, frozen citrated plasma tubes, 5 mL whole blood, and 2 mL frozen serum

Container

Gel-barrier tube or red-top tube, lavender-top (EDTA) tube or yellow-top (ACD) tube, and blue-top (sodium citrate) tube

Collection

Plasma must be separated from cells within 45 minutes of venipuncture. Plasma must be centrifuged a second time before being placed in plastic transport tubes. Freeze within two hours and keep frozen until testing is performed. Allow gel-barrier tube or red-top tube to clot, centrifuge, and remove serum from cells within one hour. Send serum in plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze serum and plasma. Maintain whole blood at room temperature; stable for seven days.

Causes for Rejection

Noncitrated plasma; gross hemolysis; fibrin clot; clotted samples if adequate DNA not obtained

Clinical Information

Special Instructions

Informed consent is required for New York patients. Test will reflex to Factor V Leiden Gene Mutation if APCR is abnormal. If abnormal, aPTT will reflex to Immediate aPTT Mixing Studies. If reflex test is performed, concomitant CPT codes/charges will apply.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
501790 Venous Thrombosis Profile 501701 Homocysteine umol/L 13965-9
501790 Venous Thrombosis Profile 500666 Factor VIII Activity % 3209-4
501790 Venous Thrombosis Profile 500573 Antithrombin Activity, Plasma % 27811-9
501790 Venous Thrombosis Profile 500464 Prt C Activity (Chromogenic) % 27818-4
501790 Venous Thrombosis Profile 500618 Protein S Antigen, Free % 27821-8
501790 Venous Thrombosis Profile 500513 APTT sec 14979-9
501790 Venous Thrombosis Profile 500363 APTT 1:1 NP sec 5946-9
501790 Venous Thrombosis Profile 500364 APTT 1:1 Saline Sec 43734-3
501790 Venous Thrombosis Profile 502038 LAC Interpretation 3281-3
501790 Venous Thrombosis Profile 501172 Act. Prt C Resist w/FV Defic. ratio 13590-5
501790 Venous Thrombosis Profile 501549 DRVVT Screen Seconds sec 6303-2
501790 Venous Thrombosis Profile 501548 DRVVT Confirm Seconds sec 57838-5
501790 Venous Thrombosis Profile 500585 DRVVT Ratio ratio 50410-0
501790 Venous Thrombosis Profile 500569 Hexagonal Phospholipid Neutral sec 3282-1
501790 Venous Thrombosis Profile 500575 Anticardiolipin Ab, IgG GPL 3181-5
501790 Venous Thrombosis Profile 500571 Anticardiolipin Ab, IgM MPL 3182-3
501790 Venous Thrombosis Profile 500589 Beta-2 Glycoprotein I, IgG SGU 16135-6
501790 Venous Thrombosis Profile 500593 Beta-2 Glycoprotein I, IgM SMU 16136-4
501790 Venous Thrombosis Profile 500591 Beta-2 Glycoprotein I, IgA SAU 21108-6
501790 Venous Thrombosis Profile 500583 Factor II Gene Mutation Result 24476-4
501790 Venous Thrombosis Profile 500624 Interpretation: 51968-6
501790 Venous Thrombosis Profile 500625 Methodology: 49549-9
501790 Venous Thrombosis Profile 500626 Comments: 77202-0
Reflex Table for Act. Prt C Resist w/FV Defic.
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 500586 Factor V Leiden 500587 Factor V Leiden Result 21667-1
Reflex Table for Act. Prt C Resist w/FV Defic.
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 500586 Factor V Leiden 500627 Interpretation: 51968-6
Reflex Table for Act. Prt C Resist w/FV Defic.
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 500586 Factor V Leiden 500628 Methodology: 49549-9
Reflex Table for Act. Prt C Resist w/FV Defic.
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 500586 Factor V Leiden 500629 Comments: 77202-0
Reflex Table for Act. Prt C Resist w/FV Defic.
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 500586 Factor V Leiden 500811 Factor V Leiden N/A

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