Venous Thrombosis Profile (Esoterix)

CPT: 81240; 83090; 85240; 85300; 85303; 85306; 85307; 85598; 85613(x2); 85730; 85732(x2); 86146(x3); 86147(x2)
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Test Details

Test Includes

Activated partial thromboplastin time (aPTT); anticardiolipin antibodies IgG, IgM; antithrombin activity; β2-glycoprotein I, IgA, IgG, IgM; dilute Russell's viper venom time (dRVVT) confirm seconds; dilute Russell's viper venom time (dRVVT) ratio; dilute Russell's viper venom time (dRVVT) screen seconds; factor II gene mutation; factor VIII activity; hexagonal phospholipid neutralization; homocysteine; protein C activity (chromogenic); protein C resistance with factor V deficiency; protein S antigen, free


See individual tests.

Specimen Requirements


Serum, plasma, and whole blood


Three 2-mL platelet-poor, frozen citrated plasma tubes, 5 mL whole blood, and 2 mL frozen serum


Gel-barrier tube or red-top tube, lavender-top (EDTA) tube or yellow-top (ACD) tube, and blue-top (sodium citrate) tube


Plasma must be separated from cells within 45 minutes of venipuncture. Plasma must be centrifuged a second time before being placed in plastic transport tubes. Freeze within two hours and keep frozen until testing is performed. Allow gel-barrier tube or red-top tube to clot, centrifuge, and remove serum from cells within one hour. Send serum in plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze serum and plasma. Maintain whole blood at room temperature; stable for seven days.

Causes for Rejection

Noncitrated plasma; gross hemolysis; fibrin clot; clotted samples if adequate DNA not obtained

Clinical Information

Special Instructions

Informed consent is required for New York patients. Test will reflex to Factor V Leiden Gene Mutation if APCR is abnormal. If abnormal, aPTT will reflex to Immediate aPTT Mixing Studies. If reflex test is performed, concomitant CPT codes/charges will apply.

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CPT Statement/Profile Statement

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