Thrombotic Risk Profile, DNA Analysis

CPT: 81240; 81241; 81291
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Test Details

Test Includes

Factor II, DNA analysis; factor VLeiden mutation analysis; methylenetetrahydrofolate reductase (MTHFR) thermolabile variant, DNA analysis


Evaluation of patients with venous thrombosis


This assay detects the R506Q (Leiden) mutation in the factor V gene, the G20210A mutation in the factor II (prothrombin) gene, and the C677T and A1298C mutations in the MTHFR gene.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).


Polymerase chain reaction (PCR) and gel electrophoresis

Additional Information

See Related Information for individual components of this profile.

Specimen Requirements


Whole blood or LabCorp buccal swab kit (buccal swab collection kit contains instructions for use of a buccal swab)


7 mL whole blood or LabCorp buccal swab kit

Minimum Volume

3 mL whole blood or two buccal swabs


Lavender-top (EDTA) tube, yellow-top (ACD) tube, or LabCorp buccal swab kit

Storage Instructions

Maintain specimen at room temperature or refrigerate.

Causes for Rejection

Frozen specimen; hemolysis; quantity not sufficient for analysis; improper container; one buccal swab; wet buccal swab


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
512103 Thrombotic Risk Panel, DNA 511559 Factor V Leiden Mutation 21667-1
512103 Thrombotic Risk Panel, DNA 511218 Factor II, DNA Analysis 24476-4
512103 Thrombotic Risk Panel, DNA 512063 MTHFR, DNA Analysis 21709-1

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The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at