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Thrombotic Risk, Congenital
Activated protein C resistance (APCR) with reflex to factor VLeiden mutation analysis; antithrombin activity; factor II (prothrombin), DNA analysis; homocyst(e)ine, plasma; plasminogen activity; protein C, functional; protein S, free
Expected Turnaround Time
4 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
For more information, please view the literature below.
Plasma, frozen, and serum, refrigerated, and whole blood or buccal swab kit (buccal swab collection kit contains instructions for the use of a buccal swab)
2 mL frozen sodium citrate plasma and 2 mL serum and 7 mL whole blood or buccal swab
Blue-top (sodium citrate) tube, gel-barrier tube, lavender-top (EDTA) tube, yellow-top (ACD) tube, or LabCorp buccal swab kit
Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tubes. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and (using a plastic transfer pipette) carefully remove two-thirds of the plasma without disturbing the cells. Deliver to a plastic transfer tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a LabCorp PP transpak frozen purple tube with screw cap (LabCorp N° 23751). The specimen should be frozen immediately and maintained frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.
Freeze plasma. Refrigerate serum. Maintain whole blood and buccal swab kit at room temperature or refrigerate.
Do not draw from an arm with a heparin lock or heparin lock or heparinized catheter.
See individual tests.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|117706||Thrombotic Risk (Congenital)||015040||Antithrombin Activity||%||27811-9|
|117706||Thrombotic Risk (Congenital)||117705||Protein C-Functional||%||27819-2|
|117706||Thrombotic Risk (Congenital)||117714||Plasminogen||%||5970-9|
|117706||Thrombotic Risk (Congenital)||117763||Act.Prt.C Resist.||ratio||13590-5|
|117706||Thrombotic Risk (Congenital)||117871||FVDNA TRACKING||N/A|
|117706||Thrombotic Risk (Congenital)||164519||Protein S, Free||%||27821-8|
|117706||Thrombotic Risk (Congenital)||511218||Factor II, DNA Analysis||24476-4|
|117706||Thrombotic Risk (Congenital)||707009||Homocyst(e)ine||umol/L||13965-9|
|Reflex Table for Act.Prt.C Resist.|
|Order Code||Order Name||Result Code||Result Name||UofM||Result LOINC|
|Reflex 1||511260||Factor V Leiden Mutation||511262||Factor V Leiden||21667-1|