Red Blood Cell (RBC) Antigen Typing

CPT: 86905
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Test Details

Synonyms

  • Antigen Typing, RBC

Use

Typing paternal RBCs for antigens that correspond to maternal antibody may aid in the prediction of hemolytic disease of the fetus and newborn.

Limitations

Presence of potent cold autoagglutinins, positive direct antiglobulin test, and, in some cases, bacteremia may interfere with test interpretation. Typing for high or low frequency antigens may not be possible due to the unavailability of appropriate antisera.

Methodology

Hemagglutination/antiglobulin test

Specimen Requirements

Specimen

Whole blood

Volume

1 mL

Minimum Volume

0.5 mL

Container

Lavender-top (EDTA) tube

Storage Instructions

Specimens should be tested as soon as possible or within 72 hours of collection. Samples that cannot be tested immediately should be stored at 2°C to 8°C. Do not freeze red cells.

Causes for Rejection

Gross hemolysis; bacterial or other contamination

Clinical Information

Special Instructions

Tests are now available for each antigen pair; refer to the appropriate test number. If the antigen being requested does not have a test number, specify the antigen to be tested in the clinical comments section of the test request form. Red cell antigen typing is available for the following additional antigens: k(Cellano) and P1. For E/e Antigen, refer to 006018, C/c Antigen, refer to 006010, K Antigen, refer to 006068, Fya/Fyb Antigen, refer to 006025, Jka/Jkb Antigen, refer to 006030, M Antigen, refer to 006048, N Antigen, refer to 006060, S/s Antigen, refer to 006040, Lea/Leb Antigen, refer to 006034, A1 Antigen, refer to 006002.

Note: This testing is usually ordered to test red cells from the partner of a prenatal patient who has developed atypical red cell antibodies. Red cell antigen typing may also be indicated for bone marrow, tissue, organ, or blood donors prior to donation. Testing a prenatal patient for red cell antigens is generally not indicated.

References

Fung MK, Grossman JB, Hillyer CD, Westoff CM, eds. AABB Technical Manual. 18th ed. Bethesda, Md: American Association of Blood Banks;2014.
Reid ME, Lomas-Frances CG, Olsson ML, eds. Blood Group Antigen Facts Book. 3rd ed. London, England: Academic Press;2012.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006262 Antigen Typing,(RBC) 33062-1 006262 Antigen Typing,(RBC) 33062-1

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