Recurrent Miscarriage/Fetal Demise Profile (Esoterix)

CPT: 81240; 81241; 83090; 85290; 85300; 85303; 85306; 85415; 85598; 85613(x2); 85730; 85732(x2); 86146(x3); 86147(x3); 86148(x2)
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Test Details

Synonyms

  • Obstetric Complications Profile

Test Includes

Activated partial thromboplastin time (aPTT); anticardiolipin antibodies IgA, IgG, IgM; antiphosphatidylserine, IgG, IgM; antithrombin activity; APTT mixing studies; β2-glycoprotein I, IgA, IgG, IgM; dRVVT; factor II gene mutation (prothrombin G20210A); factor V mutation (Leiden); factor XIII activity; hexagonal phospholipid neutralization; homocysteine; lupus anticoagulant interpretation; plasminogen activator inhibitor-1 (PAI-1) activity; protein C activity (chromogenic); protein S antigen, free

Limitations

This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

Methodology

See individual tests.

Specimen Requirements

Specimen

Serum, plasma, and whole blood

Volume

Five 1-mL tubes of platelet-poor frozen citrated plasma and 5 mL whole blood and 2 mL frozen serum

Container

Blue-top (sodium citrate) tube citrated platelet-free plasma and lavender-top (EDTA) tube or yellow-top (ACD) tube and red-top tube or gel-barrier tube.

Collection

Plasma/serum must be separated from cells within 45 minutes of venipuncture and plasma centrifuged a second time before being placed in plastic transport tubes. Freeze within two hours and keep frozen until testing is performed.

Storage Instructions

Freeze plasma or serum. Maintain whole blood at room temperature; stable for seven days.

Causes for Rejection

Noncitrated plasma; gross homolysis; presence of fibrin; clotted plasma; clotted whole blood samples if adequate DNA not obtained; frozen whole blood

Clinical Information

Special Instructions

Informed consent is required for New York patients. If abnormal, aPTT will reflex to immediate aPTT mixing studies. If reflex test is performed, additional charges/CPT code(s) may apply.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
502051 OB Complications Profile 501701 Homocysteine umol/L 13965-9
502051 OB Complications Profile 500186 Factor XIII Activity** % 3237-5
502051 OB Complications Profile 500616 PAI-1 Activity IU/mL 5975-8
502051 OB Complications Profile 500573 Antithrombin Activity, Plasma % 27811-9
502051 OB Complications Profile 500464 Prt C Activity (Chromogenic) % 27818-4
502051 OB Complications Profile 500618 Protein S Antigen, Free % 27821-8
502051 OB Complications Profile 500513 APTT sec 14979-9
502051 OB Complications Profile 500363 APTT 1:1 NP sec 5946-9
502051 OB Complications Profile 500364 APTT 1:1 Saline Sec 43734-3
502051 OB Complications Profile 501549 DRVVT Screen Seconds sec 6303-2
502051 OB Complications Profile 501548 DRVVT Confirm Seconds sec 57838-5
502051 OB Complications Profile 500585 DRVVT Ratio ratio 50410-0
502051 OB Complications Profile 500569 Hexagonal Phospholipid Neutral sec 3282-1
502051 OB Complications Profile 500575 Anticardiolipin Ab, IgG GPL 3181-5
502051 OB Complications Profile 500571 Anticardiolipin Ab, IgM MPL 3182-3
502051 OB Complications Profile 500581 Anticardiolipin Ab, IgA APL 5076-5
502051 OB Complications Profile 500589 Beta-2 Glycoprotein I, IgG SGU 16135-6
502051 OB Complications Profile 500593 Beta-2 Glycoprotein I, IgM SMU 16136-4
502051 OB Complications Profile 500591 Beta-2 Glycoprotein I, IgA SAU 21108-6
502051 OB Complications Profile 500577 Antiphosphatidylserine IgG GPS 32032-5
502051 OB Complications Profile 500579 Antiphosphatidylserine IgM MPS 32033-3
502051 OB Complications Profile 502038 LAC Interpretation 3281-3
502051 OB Complications Profile 500587 Factor V Leiden Result 21667-1
502051 OB Complications Profile 500627 Interpretation: 51968-6
502051 OB Complications Profile 500628 Methodology: 49549-9
502051 OB Complications Profile 500629 Comments: 77202-0
502051 OB Complications Profile 500583 Factor II Gene Mutation Result 24476-4
502051 OB Complications Profile 500624 Interpretation: 51968-6
502051 OB Complications Profile 500625 Methodology: 49549-9
502051 OB Complications Profile 500626 Comments: 77202-0
502051 OB Complications Profile 502052 ThrombAssure(TM) Enhanced N/A
502051 OB Complications Profile 502053 ThrombAssure(TM) Enhanced N/A
502051 OB Complications Profile 502055 ThrombAssure(TM) Enhanced N/A

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf