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Protoporphyrin, Free Erythrocyte, and Zinc Protoporphyrin
Zinc protoporphyrin and free erythrocyte protoporphyrin
Fluorescent substances in plasma may interfere with hematofluorometer results.2 Skin contamination may lead to false elevations. Both this test and blood lead are needed for full evaluation.
• FEP, blood: Adults: 0−34 μg/dL
• ZPP, blood: Adults: 0−38 μg/dL; occupational exposure: BEI® (sampling time is after one month's exposure): 100 μg/dL1
“Free” protoporphyrin is noncomplexed, nonheme protoporphyrin. Lead poisoning is also characterized by elevated plasma and urine δ-aminolevulinic acid and increased urinary coproporphyrin. Urinary porphobilinogen and uroporphyrin are normal to slightly increased.3 Free erythrocyte protoporphyrin is a sensitive test for lead toxicity or chronic exposure in adults. Erythrocyte protoporphyrin levels should not be used as a screening test for lead poisoning in children.4 The diagnosis of lead exposure or poisoning includes consideration of environmental exposure, as well as symptoms and abnormal erythrocyte protoporphyrin. This test is not to be used for workplace exposure to lead. If lead testing is required for workplace exposure to lead, please order test 010169.
Increased lead absorption is reported in the presence of iron deficiency.5
Royal blue-top (EDTA) tube or tan-top lead-free tube; submit original tube.
Mix tube thoroughly to avoid clotting.
Maintain specimen at room temperature.
Causes for Rejection
Clotted specimen; frozen specimen
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|010165||Protoporphyrin, FEP/ZPP||012090||Protoporphyrin (FEP)||ug/dL||2892-8|
|010165||Protoporphyrin, FEP/ZPP||012079||Zinc Protoporphyrin||ug/dL||2895-1|