Propoxyphene, Screen and Confirmation, Urine

CPT: 80307
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Test Details

Test Includes

Propoxyphene screen, urine; confirmation (at additional charge)

Methodology

Initial testing by immunoassay (IA); confirmation of positives by mass spectrometry (MS)

Additional Information

Propoxyphene is an analgesic structurally similar to methadone. Its metabolite, norpropoxyphene is also pharmacologically active. Toxic effects include nausea, vomiting, and progressive central nervous system depression. Peak serum level occurs two hours post oral dose, half-life is 8 to 24 hours. Propoxyphene can also be measured in urine as part of a drug of abuse test.

Specimen Requirements

Specimen

Urine

Volume

20 mL

Container

Use plastic urine drug bottle and evidence tape or tamper-evident container for forensic specimen. Collection kits are available by request from the laboratory.

Collection

Urine temperature monitoring is recommended for samples to be tested for medicolegal purposes.

Storage Instructions

Maintain specimen at room temperature. If arrival extends beyond seven days, then refrigerate.

Causes for Rejection

Quantity not sufficient for analysis; improper specimen (serum, plasma, blood); incomplete chain-of-custody documentation; incomplete specimen identification; improper or missing tamper-evident seals

Clinical Information

Special Instructions

Chain-of-custody documentation is required for samples submitted for preëmployment, random employee testing, and forensic purposes. For other applications, use the standard request form. Please mark chain-of-custody test number on the test request form.

References

Gilman AG, Goodman LS, Rall TW, et al. The Pharmacological Basis of Therapeutics. 7th ed. New York, NY: Macmillan Publishing;1985:519-520.
Hartman B, Miyada DS, Pirkle H, et al. Serum propoxyphene concentrations in a cohort of opiate addicts on long-term propoxyphene maintenance therapy. Evidence for drug tolerance in humans. J Anal Toxicol. 1988 Jan-Feb; 12(1):25-29. 3352239
Krantz T, Thisted B, Strøm J, Angelo H, Sørensen MB. Severe acute propoxyphene overdose treated with dopamine. J Toxicol Clin Toxicol. 1985; 23(4-6):347-352. 4057324
Kurlan R, Majumdar L, Deeley C, et al. A controlled trial of propoxyphene and naltrexone in patients with Tourette's syndrome. Ann Neurol. 1991 Jul; 30(1):19-23. 1681781
Oles KS, Mirza W, Penry JK. Catastrophic neurologic signs due to drug interaction: Tegretol® and Darvon®. Surg Neurol. 1989 Aug; 32(2):144-151.2749458

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
074492 Propoxyphene 733812 Propoxyphene, Urine ng/mL 19429-0
Reflex Table for Propoxyphene, Urine
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 074567 Propoxyphene Confirmation, Ur 777227 Propoxyphene or Meta 19141-1
Reflex Table for Propoxyphene, Urine
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 074567 Propoxyphene Confirmation, Ur 074583 Propoxyphene or Metab. GC/MS ng/mL 3545-1
Reflex Table for Propoxyphene, Urine
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 074567 Propoxyphene Confirmation, Ur 070474 Documentation N/A
Reflex Table for Propoxyphene, Urine
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 074567 Propoxyphene Confirmation, Ur 711793 Propoxyphene GC/MS Holding N/A

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