Pentobarbital, Serum or Plasma

CPT: 80345
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Synonyms

  • Nembutal®

Expected Turnaround Time

2 - 4 days


Related Documents


Specimen Requirements


Specimen

Serum or plasma


Volume

2 mL


Minimum Volume

0.6 mL


Container

Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.


Collection

Transfer separated serum or plasma to a plastic transport tube. Collect specimen immediately prior to next dose unless otherwise indicated.


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Gel-barrier tube; gross hemolysis; lipemia


Test Details


Use

Short-term treatment of insomnia; preoperative sedation; high-dose barbiturate coma treatment for increased intracranial pressure or status epilepticus unresponsive to other therapy


Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)


Reference Interval

Therapeutic: 1−5 μg/mL


Critical Value

Potentially toxic: >8 μg/mL

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
017194 Pentobarbital 3924-8 017194 Pentobarbital ug/mL 3924-8

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