Manganese, Plasma

CPT: 83785
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Test Details

Synonyms

  • Mn, Plasma

Use

Evaluate industrial exposure

Limitations

In evaluating toxicity, the serum level may have returned to normal while neurological damage persists. In evaluating possible deficiency states, the human deficiency syndrome is poorly defined, making interpretation difficult. Levels are reportedly reduced mildly in epilepsy, and raised in hepatitis or jaundice. Manganese levels are 60% lower than normal in hemodialysis patients.

Methodology

Inductively-coupled plasma/mass spectrometry (ICP/MS)

Reference Interval

Environmental exposure: <2.5 μg/L

Additional Information

Toxic exposure may occur from dry cells, fungicide (maneb), and in the steel industry or chemical industry. Manganese is present in the coloring agents for glass and soap, in paints, varnish, enamel, and in linoleum. It is used in the manufacture of chlorine gas and now in lead-free gasoline. Industrial manganese poisoning has been recognized since 1837. Some water supplies are sufficiently contaminated by manganese that endemic psychiatric and neurological disease is present.

Specimen Requirements

Specimen

Plasma

Volume

2 mL

Minimum Volume

0.6 mL

Container

Royal blue-top (EDTA) tube

Collection

Separate plasma immediately, and transfer to a certified metal-free plastic transport tube (PeopleSoft N° 111166) for shipment to the laboratory.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Certified metal-free plastic transport tube not submitted

Clinical Information

References

Ferraz HB, Bertolucci PH, Pereira JS, Lima JG, Andrade LA. Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology. 1988 Apr; 38(4):550-553. 3352909
Kondakis XG, Makris N, Leotsinidis M, Prinou M, Papapetropoulos T. Possible health effects of high manganese concentration in drinking water. Arch Environ Health. 1989 May-Jun; 44(3):175-178. 2751354

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
071589 Manganese, Plasma 5683-8 071589 Manganese, Plasma ug/L 5683-8

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