Human Immunodeficiency Virus 1 (HIV-1) GenoSure® MG Genotyping

CPT: Call 800-222-7566, ext 6-8400, for coding.
Updated on 5/28/2019
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Synonyms

  • HIV-1 Genotype
  • Resistance Analysis
  • Retroviral Genotype

Special Instructions

A separate frozen specimen is required for each frozen test ordered.


Expected Turnaround Time

9 - 15 days

9 - 15 days



Specimen Requirements


Specimen

Plasma, frozen


Volume

5 mL


Container

Lavender-top (EDTA) or plasma preparation tube (PPT™)


Collection

Collect specimen in three lavender-top (EDTA) tubes or three PPT™ tubes. Do not use green-top (heparin) tubes. Centrifuge specimen within six hours of collection. Transfer plasma to one or more screw-cap polypropylene transport tube(s). Snap-cap or pop-top tubes should be avoided and may result in specimen rejection. Immediately freeze specimen at -20°C. Do not place samples on dry ice until completely frozen. Specimens collected in PPT™ need to be centrifuged within six hours and frozen. Ship specimens frozen. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Freeze.


Causes for Rejection

PPT™ not centrifuged; insufficient volume; heparinized plasma; nonfrozen specimens; specimens exposed to repeated freeze/thaw cycles


Test Details


Use

Detect resistance in HIV-1 to antiretroviral drugs targeted at the reverse transcriptase (nucleoside and nonnucleoside inhibitors) and protease.


Limitations

This procedure may not be successful when the HIV viral load is <500 copies/mL plasma. If there is insufficient virus to produce results, HIV-1 RNA quantitation will be performed to confirm viral load, and the procedure will be billed at the account's prevailing fee.


Methodology

Polymerase chain reaction (PCR) amplification and DNA sequencing


References

Hirsch MS, Brun-Vézinet F, D'Aquila RT, et al. Antiretroviral drug resistance testing in adult HIV-1 infection. Recommendations of an International AIDS Society-USA panel. JAMA. 2000; 283(18):2417-2426. 10815085

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
551697 GenoSure(R) MG 53798-5 551656 HIV GenoSure(R) N/A
551697 GenoSure(R) MG 53798-5 551657 HIV GenoSure(R) 53798-5
551697 GenoSure(R) MG 53798-5 551693 HIV GenoSure(R) MG PDF 49573-9
Reflex Table for HIV GenoSure(R)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551318 Quant, RNA PCR 551312 log10 HIV-1 RNA log10copy/mL 29541-0
Reflex Table for HIV GenoSure(R)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551619 HIV GenoSure(R) MG Interp 551619 HIV GenoSure(R) MG Interp N/A

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