Human Immunodeficiency Virus 1 (HIV-1) DNA Sequencing Integrase

TEST: 551965
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Synonyms

  • Cell-associated Viral DNA
  • HIV-1 Genotype
  • Resistance Analysis

Expected Turnaround Time

10 - 14 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Coreceptor Tropism Assays

GenoSure Archive℠: Cell-associated Viral DNA Assay for HIV-1 Protease, Reverse Transcriptase, and Integrase Inhibitors

GenoSure Archive℠: HIV-1 Next Generation DNA Sequencing Assay for Suppression Management

HIV Specimen Collection Guide

HIV-1 Lifecycle, Drugs, and Susceptibility Assays

    Specimen Requirements

    Specimen

    Whole blood, frozen

    Volume

    4 mL

    Collection

    Collect specimen in lavender-top (EDTA) tube. Do not centrifuge. Ship frozen. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

    Storage Instructions

    Freeze.

    Causes for Rejection

    Quantity not sufficient for analysis; heparinized plasma; nonfrozen specimen

    Test Details

    Use

    Detect resistance of HIV-1 to integrase inhibitors in cell-associated viral DNA.

    Limitations

    This procedure should be used for patients with documented HIV-1 infection and undetectable viral load or low level viremia.

    Methodology

    Polymerase chain reaction (PCR) amplification and next generation DNA sequencing

    References

    Günthard HF, Aberg JA, Eron JJ, et al. Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel. JAMA. 2014 Jul 23-30; 312(4):410-425. 25038359
    Hurt C. Transmitted resistance to HIV integrase strand-transfer inhibitors: Right on schedule. Antivir Ther. 2011; 16(2):137-140. 21447861
    Panel on Antiretroviral Guidelines for Adults and Adolescents—A Working Group of the Office of AIDS Research Advisory Council (OARAC). Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Washington, DC: Department of Health and Human Services; May 1, 2014.

    LOINC® Map

    Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
    551965 DNA Sequencing Integrase 551968 PDF 80695-0
    551965 DNA Sequencing Integrase 551966 HIV DNA Sequencing IN N/A
    551965 DNA Sequencing Integrase 551967 HIV DNA Sequencing IN 80691-9
    551965 DNA Sequencing Integrase 551963 HIV DNA Sequencing IN Interp 80694-3
    Reflex Table for HIV DNA Sequencing IN
    Order Code Order Name Result Code Result Name UofM Result LOINC
    Reflex 1 551964 HIVDNASeq IN 551964 HIVDNASeq IN N/A
    Reflex Table for HIV DNA Sequencing IN
    Order Code Order Name Result Code Result Name UofM Result LOINC
    Reflex 1 551969 HIVDNASeq IN Interp 551969 HIVDNASeq IN Interp N/A

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