Herpes Simplex Virus (HSV) Types 1 and 2, IgM Antibodies, Indirect

CPT: 86695; 86696
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Test Details


  • HSV-1 and HSV-2 IgM Antibodies, Indirect


Semiquantitative detection of IgM antibodies to herpes 1 and 2


By design, all HSV indirect immunofluorescent antibody assays cannot be type-specific. The test is created using cell culture in which HSV type 1 or type 2 has been grown and infected some, but not all, of the cells present. When serum is reacted with this antigenic substrate, the antibodies formed by the patient will include both those that are type-specific as well as antibodies to shared not type-specific antigens of HSV-1 and HSV-2. Because of these shared antigens, many cross-reacting antibodies are formed. Elevated titers to both HSV-1 and HSV-2 may represent cross-reactive HSV antibodies rather than exposure to both HSV-1 and HSV-2.

This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.


Indirect fluorescent antibody (IFA)

Specimen Requirements




1 mL

Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Lipemia; hemolysis; bacterial contamination


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
165180 HSV 1 and 2 IgM Abs, Indirect 165181 HSV 1 IgM Antibodies titer 50758-2
165180 HSV 1 and 2 IgM Abs, Indirect 165182 HSV 2 IgM Antibodies titer 26927-4

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