Herpes Simplex Virus (HSV) Type 2-Specific Antibodies, IgG

CPT: 86696
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Test Details

Test Includes

Detection of antibodies specific to herpes type 2 only


Detect IgG antibodies specific to HSV type 2 infection; confirm or rule out possible infection with herpes simplex type 2 virus in prenatal patients in whom HSV 2 infection can cause serious prenatal disease. In a patient with no history of lesion disease, a positive result for this test may be indicative that the primary infection was asymptomatic. Once infected by HSV, it is possible for a patient to shed virus without the development of lesions (asymptomatic shedding). This test does not indicate the site of HSV infection.


Chemiluminescent immunoassay (CLIA)

Reference Interval

Negative: <0.91 index

Additional Information

There is a considerable homology between HSV-1 and HSV-2 antigens, so that antibodies formed against either virus are highly cross-reactive. This assay is based on glycoprotein G-2, purified from HSV-2 infected cells, and is specific for type 2 antibodies.

Specimen Requirements




0.5 mL

Minimum Volume

0.2 mL


Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/Thaw Cycle

Stable x4

Clinical Information


Ashley R, Cent A, Maggs V, Nahmias A, Corey L. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types 1 and 2. Ann Intern Med. 1991 Oct 1; 115(7):520-526. 1652909
Centers for Disease Control and Prevention. Sexually-transmitted disease treatment guidelines 2002. MMWR. 2002; 51(RR-6). 12184549
Corey L. The current trend in genital herpes. Progress in prevention. Sex Transm Dis. 1994 Mar-Apr; 21(2 Suppl):S38-S44. 8042114
Whitley RJ. Herpes simplex infections of women and their offspring: Implications for a developed society. Proc Natl Acad Sci USA, 1994 Mar 29; 91(7):2441-2447 (review).8146137


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
163147 HSV Type 2-Specific Ab, IgG 5209-2 163155 HSV 2 IgG, Type Spec index 5209-2

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