Hepatitis C Virus (HCV), Quantitative, RNA PCR (Graphical) With Reflex to Hepatitis C Virus (HCV) GenoSure® NS3/4A

CPT: 87522. If reflex testing is performed, concomitant CPT codes/charges will apply.
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Test Details


  • HCV Real-time PCR With Reflex to HCV GenoSure® NS3/4A
  • HCV RNA Quantitation With Reflex to HCV GenoSure® NS3/4A

Test Includes

Reflex to HCV GenoSure® NS3/4A if viral load is ≥2000 IU/mL


Quantification of HCV with reflex to HCV GenoSure NS3/4A drug resistance (at additional charge) if ≥2000 IU/mL. Detects Q80K polymorphism.


The HCV real-time PCR assay has a quantitative range of 15 IU/mL to 100,000,000 IU/mL. This assay requires an HCV genotype of either 1a or 1b.


Cobas® AmpliPrep/Cobas® Taqman® HCV Test v 2.0. See Hepatitis C Virus (HCV) GenoSure® NS3/4A [550540] for more information.

Specimen Requirements


Plasma, frozen


6 mL

Minimum Volume

3.3 mL


PPT™ or lavender-top (EDTA) tube


Centrifuge specimen within six hours of collection. Remove plasma, transfer plasma to a screw-cap polypropylene transport tube (not "pop-top" or "snap-cap"), and freeze. Specimens collected in PPT™ need to be centrifuged within six hours and frozen. Ship frozen. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions


Causes for Rejection

Hemolysis; heparinized plasma; nonfrozen specimen; PPT™ not centrifuged; specimen received in "pop-top" or "snap-cap" tube; whole blood

Clinical Information

Special Instructions

Please indicate the patient's HCV genotype (1a or 1b) on the test request form. Submit the patient's Social Security number (or unique identifier) to order serial monitoring.


Kleiber J, Walter T, Haberhausen G, Tsang S, Babiel R, Rosenstraus M. Performance characteristics of a quantitative, homogeneous TaqMan RT-PCR test for HCV RNA. J Mol Diagn. 2000 Aug; 2(3):158-166. 11229521

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