Helicobacter pylori Antibodies, IgA

CPT: 86677
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Test Details

Synonyms

  • Anti-Campylobacter Antibodies
  • Anti-H pylori, IgA

Use

Diagnose H pylori infection in patients with duodenal disease and for monitoring the eradication of H pylori following antimicrobial therapy; identify the small percentage of H pylori-infected patients who fail to mount a systemic IgG response and demonstrate IgA antibodies only and for those patients who have chronic mucosal infections

Methodology

Enzyme-linked immunosorbent assay (ELISA)

Reference Interval

• Negative: <9.0 units

• Equivocal: 9.0−11.0 units

• Positive: >11.0 units

Additional Information

Circulating antibodies to H pylori are predominantly of the IgG class. A systemic response of the IgA type is usually less pronounced but, if significant, may indicate a more severe inflammation. A few patients develop only antibodies to IgA. IgM antibodies are rarely found and appear to be of minor importance.

Specimen Requirements

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL

Container

Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

3 days

Refrigerated

3 days

Frozen

7 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Heat inactivated serum; hemolysis; lipemia; gross bacterial contamination

Clinical Information

References

Kosunen TU, Seppälä K, Sarna S, Sipponen P. Diagnostic value of decreasing IgG, IgA, and IgM antibody titres after eradication of Helicobacter pylori.Lancet. 1992 Apr 11; 339(8798):893-895. 1348298
Thomson ABR. Helicobacter pylori and gastroduodenal pathology. Can J Gastroenterol. 1993; 7(4):353-358.
von Wulffen H. An assessment of serological tests for the detection of Helicobacter pylori.Eur J Clin Microbiol Infect Dis. 1992 Jul; 11(7):577-582.1396763

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
163170 Helicobacter pylori, IgA 6420-4 163173 H. pylori, IgA Abs units 7901-2

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