Fluoride

CPT: 82735
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Test Details

Use

Monitor exposure to fluoride

Methodology

Ion-selective electrode (ISE) potentiometry

Reference Interval

Environmental exposure: <0.2 mg/L

Additional Information

Fluoride poisoning through chronic exposure to fluoride and its inorganic compounds is generally associated with industry. The effects of fluoride overexposure are generally manifested initially in mucous membrane irritation. Increased intensity of the exposure may produce respiratory distress, neurological abnormalities, gastrointestinal pain, and muscular fibrillation. Prolonged exposure over years can lead to skeletal fluorosis, a crippling disease. Acute exposure is more commonly the result of the ingestion of fluorides and is manifested by symptoms of nausea, vomiting, tetanic contractions, coma, and death.1 Fluoride and its inorganic compounds are widely employed in industry, including glass manufacture and in the aluminum, steel, and fertilizer industries. Fluoride compounds are also employed as insecticides, rodenticides, and delousing powders. In an organic state, fluoride is an essential mineral in man required for bone calcification processes. Overexposure is generally attributed to occupational causes, which are typically of a chronic nature. Acute exposure is more commonly the result of the ingestion of fluorides.

Specimen Requirements

Specimen

Serum or plasma

Volume

3 mL

Minimum Volume

1.1 mL

Container

Royal blue-top (EDTA) tube or royal blue-top without EDTA

Collection

Submit original unopened tube or serum or plasma removed from a royal blue-top tube.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

7 days

Frozen

14 days

Freeze/thaw cycles

Stable x1

Clinical Information

Footnotes

1. Baselt RC, Cravey RH. Disposition of Toxic Drugs and Chemicals in Man. 4th ed. Chemical Toxicology Institute;1995.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
070060 Fluoride, Serum 5649-9 070060 Fluoride, Serum mg/L 5649-9

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