Find Locations
For hours, walk-ins and appointments.Expected Turnaround Time
8 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum (preferred) or plasma, frozen
Volume
1 mL
Minimum Volume
0.3 mL (Note: This volume does not allow for repeat testing.)
Collection
Serum or plasma must be separated from cells within two hours of venipuncture. Submit serum or plasma in a plastic transport tube.
Storage Instructions
Freeze. Stable frozen for 14 days. Stable at room temperature or refrigerated for 14 days. Freeze/thaw cycles stable x3.
Causes for Rejection
Gross hemolysis
Test Details
Use
21-Deoxycortisol is a marker for the 21-hydroxylase deficiency (congenital adrenal hyperplasia [CAH]). The steroid is less than 10 in 98% of subjects without known CYP21A2 gene deficiency. 21-Deoxycortisol has been reported to be elevated in late-onset CAH.1 21-Deoxycortisol has been reported 2 to be elevated after ACTH stimulation in samples from patients that are heterozygous for CYP21A2 gene mutations and from patients with nonclassical CAH.
Methodology
High-pressure liquid chromatography (HPLC)/tandem mass spectrometry (MS-MS)
Footnotes
1. Fiet J, Gueux B, Gourmelen M, et al. Comparison of basal and adrenocorticotropin-stimulated plasma 21-deoxycortisol and 17-hydroxyprogesterone values as biological markers of late-onset adrenal hyperplasia. J Clin Endocrinol Metab. 1988 Apr; 66(4):L659-657. 2831244
2. Costa-Barbosa FA, Tonetto-Fernandes VF, Carvalho VM, et al. Superior discriminating value of ACTH-stimulated serum 21-deoxycortisol in identifying heterozygote carriers for 21-hydroxylase deficiency. Clin Endocrinol (Oxf). 2010 Dec; 73(6):700-706. 20846292
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 504045 | 21 Deoxycortisol, LCMS | 504046 | 21 Deoxycortisol, LCMS | ng/dL | 74872-3 |
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