Chromosome Analysis, Tissue Biopsies (Products of Conception, Skin)

TEST: 052052
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CPT: Contact CPT coding department at 800-222-7566, ext 6-8400.
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Synonyms

  • Long-term Culture, Fibroblast Karyotype Study
  • Placental Tissue Chromosome Analysis
  • Spontaneous Abortion Chromosome Analysis
  • Tissue Karyotype

Test Includes

20 Metaphases counted per study; 2 to 3 banded karyotypes per study

Special Instructions

Please include clinical information, previous cytogenetic report, or karyotype.

If prior NIPT studies have been performed, include copy of the report.

Call 800-345-4363, if there any any questions. FISH from paraffin blocks can be ordered on fixed specimen with Fluorescence in situ Hybridization (FISH), Paraffin Block [510825].

Expected Turnaround Time

11 - 16 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Tissue, skin, products of conception, placental biopsy

Volume

2 to 4 mm³

Container

Sterile container with sterile Ringer's lactate or Hanks' balanced salt solution or transport medium provided by the cytogenetics laboratory. Do not use urine containers for shipping.

Collection

Aseptically obtain a small piece of tissue with subepidermal layers. Best results are obtained from placental villi, which remain viable much longer than fetal tissue. This is especially true in stillborn cases in which both cord blood and tissue samples are often not viable. If specimen is a product of conception, submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' basal salt solution, or LabCorp transport medium.

Storage Instructions

Refrigerate. Do not freeze.

Causes for Rejection

Gross contamination; necrotic tissue; specimen in fixative

Test Details

Use

Evaluate possible chromosomal abnormalities as the cause of miscarriage. Extended study of mosaicism found in blood chromosome analysis.

Limitations

Some products of conception may only contain maternal tissue.

Methodology

Tissue culture following enzymatic digestion of tissue. Standard harvesting and G-banding procedures are used with 20 metaphases examined and two karyotypes prepared.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
052052 Chromosome, Biopsies, POC/Skin 62386-8 052072 Cells Counted 62361-1
052052 Chromosome, Biopsies, POC/Skin 62386-8 052073 Cells Karyotyped 55199-4
052052 Chromosome, Biopsies, POC/Skin 62386-8 052074 Cells Analyzed 62360-3
052052 Chromosome, Biopsies, POC/Skin 62386-8 052075 GTG Band Resolution Achieved 62358-7
052052 Chromosome, Biopsies, POC/Skin 62386-8 052077 Cytogenetic Result 62356-1
052052 Chromosome, Biopsies, POC/Skin 62386-8 052018 Cytogenetic Interpretation 62357-9
052052 Chromosome, Biopsies, POC/Skin 62386-8 052079 Specimen Type 48002-0
052052 Chromosome, Biopsies, POC/Skin 62386-8 052028 Director Review: 48672-0
052052 Chromosome, Biopsies, POC/Skin 62386-8 512123 PDF 51967-8

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