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Chlordiazepoxide and metabolites; demoxepam; N-desmethylchlordiazepoxide; N-desmethyldiazepam
Evaluate toxicity; monitor therapeutic levels
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
This drug is commonly used in suicide attempts. Chlordiazepoxide is slowly absorbed and may take several hours to reach a peak plasma level. Distribution after intramuscular administration is poor. Drug half-life in blood ranges from 16 to 27 hours. The drug is highly (90%) protein bound. Overdosage with the benzodiazepines is frequent, but serious sequelae are rare; however, there is an additive effect when used with other CNS depressants (eg, ethanol). If a patient is comatose after a drug ingestion, chlordiazepoxide alone is not a sufficient explanation. Metabolism results in the production of four active metabolites. This drug is used as an antianxiety agent for treatment of withdrawal symptoms of acute alcoholism.
Half-life elimination: 6.9 to 28 hours
Time to peak: 0.5 to 2 hours
Serum or plasma
Transfer separated serum or plasma to a plastic transport tube. Oral: peak: four hours; trough: immediately prior to next dose.
Causes for Rejection
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|007682||Chlordiazepoxide, Serum||019661||Chlordiazepoxide, S||ug/mL||3457-9|
|007682||Chlordiazepoxide, Serum||019687||Nordiazepam, Serum||ug/mL||3537-8|
|007682||Chlordiazepoxide, Serum||019689||Sum of Metabolites||ug/mL||33060-5|