Carbohydrate-deficient Transferrin (CDT), Adult

CPT: 82373
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Test Details

Synonyms

  • Diasialotransferrin
  • Transferrin Isoforms

Use

An indicator of chronic alcohol abuse

Limitations

This test is not suitable for the evaluation of patients suspected of having CDG syndrome (congenital disorders of glycosylation), genetic variants of transferrin, some monoclonal component, or high polyclonal increases, liver injuries (cirrhosis due to chronic alcohol abuse, end-stage disease).

Methodology

Capillary electrophoresis (CE)

Reference Interval

• Normal: <1.4%

• Inconclusive: 1.4% to 1.6%

• Elevated: >1.6%

Additional Information

CDT testing can be an effective tool for the early diagnosis of chronic alcohol misuse, for the detection of patients addicted to alcohol, and for the follow-up of treatment and diagnosis of alcohol relapse.

CDT quantitation is useful in detecting abusive alcohol consumption (defined as ethanol consumption >40 mL per day for at least two weeks) and a more specific marker for alcohol exposure than other available markers, such as γ-glutamyl transferase (GGT). It enables early detection of alcohol misuses and follow-up of alcoholic patients.

On stopping alcohol consumption, the CDT level goes back to normal after two to four weeks. If the patient starts drinking after withdrawal, CDT increases in a few days.

Transferrin is an 80-kDa serum glycoprotein produced by the liver. Its function is to carry iron around an organism mediated by iron-binding properties. Transferrin comprises a single polypeptide chain with two polysaccharide chains ended by a sialic acid residue. There are several isoforms of human transferrin with different levels of sialylation. Carbohydrate-deficient transferrin (CDT), defined by 2 sialo and 0 sialo isoforms, is a marker of chronic alcohol abuse.

Specimen Requirements

Specimen

Serum, frozen

Volume

1 mL

Minimum Volume

0.75 mL

Container

Red-top tube or gel-barrier tube

Collection

Serum should be separated from cells within two hours of venipuncture. Send serum frozen in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze.

Stability Requirements

Temperature

Period

Room temperature

2 days

Refrigerated

2 days

Frozen

7 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Fibrinogen present in sample; hemolyzed specimen; aged and improperly stored specimen; anticoagulated specimen (citrate, EDTA); presence of genetic variants of transferrin

Clinical Information

Special Instructions

This test is intended for evaluation of alcohol abuse. To evaluate patients for congenital disorders, physicians should contact LabCorp customer service.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
123211 Carbohydrate Deficient Transf. 48495-6 123217 CDT % 48495-6
Reflex Table for CDT
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 123213 Comment 123213 Comment N/A
Reflex Table for CDT
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 123214 Comment 123214 Comment N/A
Reflex Table for CDT
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 123215 Comment 123215 Comment N/A

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf