Bleeding Diathesis With Normal aPTT/PT Profile (Esoterix)

CPT: 85240(x2); 85245; 85246; 85250; 85270; 85290; 85360; 85384; 85410; 85415
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Test Details

Test Includes

α2-Antiplasmin assay; euglobulin lysis time; factor VIII activity; factor VIII chromogenic; factor IX activity; factor XI activity; factor XIII activity; fibrinogen activity; PAI-1 activity with reflex to PAI-1 antigen and tissue plasminogen activator (tPA); von Willebrand factor activity; von Willebrand factor antigen

Use

To assist in the determination of a cause of bleeding in a patient with normal aPTT and PT.

Limitations

This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

Methodology

See individual tests.

Specimen Requirements

Specimen

Plasma, frozen

Volume

7 mL platelet-poor frozen citrated plasma divided into seven tubes

Container

Blue-top (sodium citrate) tube

Collection

Plasma must be separated from cells within 45 minutes of venipuncture and plasma centrifuged a second time before being placed in plastic transport tubes. Freeze within two hours and keep frozen until testing is performed.

Storage Instructions

Freeze.

Causes for Rejection

Noncitrated plasma; gross hemolysis; fibrin clot in plasma

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
503541 Bleeding Diathesis 500666 Factor VIII Activity % 3209-4
503541 Bleeding Diathesis 500193 FVIII Chromogenic % 49865-9
503541 Bleeding Diathesis 500672 Factor IX Activity % 3187-2
503541 Bleeding Diathesis 500674 Factor XI Activity % 3226-8
503541 Bleeding Diathesis 500186 Factor XIII Activity** % 3237-5
503541 Bleeding Diathesis 500701 Fibrinogen Activity mg/dL 3255-7
503541 Bleeding Diathesis 500669 von Willebrand Factor Activity % 6014-5
503541 Bleeding Diathesis 500668 von Willebrand Factor Antigen % 27816-8
503541 Bleeding Diathesis 501175 Alpha-2 Antiplasmin Assay % 27810-1
503541 Bleeding Diathesis 500616 PAI-1 Activity IU/mL 5975-8
503541 Bleeding Diathesis 503479 Euglobulin Lysis Time 40454-1
503541 Bleeding Diathesis 503527 Seven Plasma Putaways Esoterix N/A
Reflex Table for PAI-1 Activity
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 503551 PAI-1+TPA Ag 500030 TPA Antigen ng/mL 5971-7
Reflex Table for PAI-1 Activity
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 503551 PAI-1+TPA Ag 500059 PAI-1 Antigen ng/mL 22758-7

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The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf