Bleeding Diathesis With Normal aPTT/PT Profile (Esoterix)

CPT: 85240(x2); 85245; 85246; 85250; 85270; 85290; 85360; 85384; 85410; 85415
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Test Details

Test Includes

α2-Antiplasmin assay; euglobulin lysis time; factor VIII activity; factor VIII chromogenic; factor IX activity; factor XI activity; factor XIII activity; fibrinogen activity; PAI-1 activity with reflex to PAI-1 antigen and tissue plasminogen activator (tPA); von Willebrand factor activity; von Willebrand factor antigen


To assist in the determination of a cause of bleeding in a patient with normal aPTT and PT.


This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.


See individual tests.

Specimen Requirements


Plasma, frozen


7 mL platelet-poor frozen citrated plasma divided into seven tubes


Blue-top (sodium citrate) tube


Plasma must be separated from cells within 45 minutes of venipuncture and plasma centrifuged a second time before being placed in plastic transport tubes. Freeze within two hours and keep frozen until testing is performed.

Storage Instructions


Causes for Rejection

Noncitrated plasma; gross hemolysis; fibrin clot in plasma

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