Benzene Metabolite Profile, Urine

CPT: 82570; 84600
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Test Details

Test Includes

Creatinine, urine; phenol, urine; phenol:creatinine ratio


Monitor exposure to benzene


Gas chromatography (GC)

Reference Interval

Environmental exposure: <20.0 mg/L

Additional Information

Phenol is the primary metabolite of benzene. Phenol comprises approximately 51% to 87% of an absorbed dose of benzene. The hematopoietic system is the chief target for benzene's toxic effects, which are manifested by alterations in the levels of formed elements in the peripheral blood. These effects have occurred at concentrations of benzene that may not cause irritation of mucous membranes, or any unpleasant sensory effects.1 Refer to footnote 1 for specific hematological guidelines.

Specimen Requirements


Urine (random)


15 mL

Minimum Volume

5.2 mL


Plastic urine container, no preservative


Sampling time is end of shift for industrial exposure monitoring. Metabolites with timing “end of shift” (meaning the last two hours of exposure) are eliminated rapidly with a half-life less than five hours. Such metabolites do not accumulate in the body and, therefore, their timing is critical only in relation to the exposure period.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements



Room temperature

7 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Clinical Information

Special Instructions

Note: For emergency examinations following benzene exposure, use the Benzene Standard Profile [324095].


1. US Department of Labor, Occupational Safety and Health Administration Regulations (Standards-26 CFR). Medical Surveillance Guidelines for Benzene−1910.1028 App.C.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
007732 Benzene Metabolite Profile, Ur 007733 Phenol (Total), U mg/L 2758-1
007732 Benzene Metabolite Profile, Ur 723280 Creatinine(Crt),U g/L 2161-8
007732 Benzene Metabolite Profile, Ur 007743 Phenol/Crt Ratio mg/g creat 13487-4

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