Benzene Metabolite Profile, Urine

CPT: 82570; 84600
Print Share

Test Details

Test Includes

Creatinine, urine; phenol, urine; phenol:creatinine ratio

Use

Monitor exposure to benzene

Methodology

Gas chromatography (GC)

Reference Interval

Environmental exposure: <20.0 mg/L

Additional Information

Phenol is the primary metabolite of benzene. Phenol comprises approximately 51% to 87% of an absorbed dose of benzene. The hematopoietic system is the chief target for benzene's toxic effects, which are manifested by alterations in the levels of formed elements in the peripheral blood. These effects have occurred at concentrations of benzene that may not cause irritation of mucous membranes, or any unpleasant sensory effects.1 Refer to footnote 1 for specific hematological guidelines.

Specimen Requirements

Specimen

Urine (random)

Volume

15 mL

Minimum Volume

5.2 mL

Container

Plastic urine container, no preservative

Collection

Sampling time is end of shift for industrial exposure monitoring. Metabolites with timing “end of shift” (meaning the last two hours of exposure) are eliminated rapidly with a half-life less than five hours. Such metabolites do not accumulate in the body and, therefore, their timing is critical only in relation to the exposure period.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Clinical Information

Special Instructions

Note: For emergency examinations following benzene exposure, use the Benzene Standard Profile [324095].

Footnotes

1. US Department of Labor, Occupational Safety and Health Administration Regulations (Standards-26 CFR). Medical Surveillance Guidelines for Benzene−1910.1028 App.C.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
007732 Benzene Metabolite Profile, Ur 007733 Phenol (Total), U mg/L 2758-1
007732 Benzene Metabolite Profile, Ur 723280 Creatinine(Crt),U g/L 2161-8
007732 Benzene Metabolite Profile, Ur 007743 Phenol/Crt Ratio mg/g creat 13487-4
Reflex Table for Creatinine(Crt),U
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 723284 Comment: 723284 Comment: N/A

For Providers

Please login to order a test.

 

© 2017  Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf