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Creatinine, urine; phenol, urine; phenol:creatinine ratio
Monitor exposure to benzene
Gas chromatography (GC)
Environmental exposure: <20.0 mg/L
Phenol is the primary metabolite of benzene. Phenol comprises approximately 51% to 87% of an absorbed dose of benzene. The hematopoietic system is the chief target for benzene's toxic effects, which are manifested by alterations in the levels of formed elements in the peripheral blood. These effects have occurred at concentrations of benzene that may not cause irritation of mucous membranes, or any unpleasant sensory effects.1 Refer to footnote 1 for specific hematological guidelines.
Sampling time is end of shift for industrial exposure monitoring. Metabolites with timing “end of shift” (meaning the last two hours of exposure) are eliminated rapidly with a half-life less than five hours. Such metabolites do not accumulate in the body and, therefore, their timing is critical only in relation to the exposure period.
Maintain specimen at room temperature.
Note: For emergency examinations following benzene exposure, use the Benzene Standard Profile .
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|007732||Benzene Metabolite Profile, Ur||007733||Phenol (Total), U||mg/L||2758-1|
|007732||Benzene Metabolite Profile, Ur||723280||Creatinine(Crt),U||g/L||2161-8|
|007732||Benzene Metabolite Profile, Ur||007743||Phenol/Crt Ratio||mg/g creat||13487-4|