DDAVP Challenge Profile for Von Willebrand Disease

TEST: 504836
Test number copied
CPT: 80503; 85240(x3); 85245(x3); 85246(x3)
Print Share

Related Documents

Specimen Requirements

Specimen

Citrated plasma, frozen

Volume

2 mL per timepoint

Minimum Volume

1.5 mL per timepoint (Note: This volume does not allow for repeat testing.)

Container

Blue-top (sodium citrate) tube

Collection

Centrifuge at 2500 xg for 10 minutes. Separate plasma from cells within 3 hours of venipuncture. Centrifuge plasma a second time and place in plastic transport tubes. Freeze within 4 hours and keep frozen until testing is performed.

Storage Instructions

Plasma, frozen

Stability Requirements

Temperature

Period

Frozen

6 months

Freeze/thaw cycles

Stable x1

Test Details

Use

This profile is designed to assess the response of DDAVP treatment in patients presenting with Von Willebrand Disease by measuring VWF and factor VIII levels pre-treatment (baseline) and at two time-points (1 hr and 4 hr) post-treatment. Post-treatment VWF levels are evaluated against baseline results to determine whether the response is adequate and sustained. Results should be correlated with clinical symptoms and family history.

Methodology

Clotting, platelet agglutination, latex immunoagglutination

Additional Information

This profile contains testing for FVIII Activity, VWF Activity and VWF Antigen at three timepoints: baseline, 1 hour and 4 hours post-treatment with DDAVP. It also contains a pathologist Interpretation of all test results.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
504836 DDAVP Challenge for VWD 500684 Pathologist Interpretation 21026-0
504836 DDAVP Challenge for VWD 504841 Factor VIII Act, Timepoint 1 % 3209-4
504836 DDAVP Challenge for VWD 504831 vWF Activity, Timepoint 1 % 6014-5
504836 DDAVP Challenge for VWD 504827 vWF Antigen, Timepoint 1 % 27816-8
504836 DDAVP Challenge for VWD 504842 Factor VIII Act, Timepoint 2 % 3209-4
504836 DDAVP Challenge for VWD 504832 vWF Activity, Timepoint 2 % 6014-5
504836 DDAVP Challenge for VWD 504828 vWF Antigen, Timepoint 2 % 27816-8
504836 DDAVP Challenge for VWD 504843 Factor VIII Act, Timepoint 3 % 3209-4
504836 DDAVP Challenge for VWD 504833 vWF Activity, Timepoint 3 % 6014-5
504836 DDAVP Challenge for VWD 504829 vWF Antigen, Timepoint 3 % 27816-8

For Providers

Please login to order a test

Order a Test

© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf