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- c-ANCA-Specific Antibody
- Proteinase 3 Antibodies
Expected Turnaround Time
2 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
0.6 mL
Minimum Volume
0.3 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Test Details
Use
Antineutrophil cytoplasmic antibodies (ANCA) are a group of antibodies directed against cytoplasm antigens of neutrophilic granulocytes and monocytes. ANCA examinations are considered basic tests in immunological laboratories. The determination of ANCA is of great importance, in particular in the case of suspected acute vasculitis of small vessels, with severe pulmonary impairment or renal failure, but also in some non-vasculitis clinical syndromes such as inflammatory bowel diseases, e.g. ulcerative colitis. The most common target antigens of ANCA-associated vasculitis are proteinase 3 or myeloperoxidase. Antibodies against proteinase 3 (PR3) are referred to as c-ANCA fluorescent subtype, namely cytoplasmic antibodies (granular cytoplasmic fluorescence). PR3 is a neutral serine proteinase 3, also known as Wegener's autoantigen. Antibodies against PR3 are a highly specific marker in diagnosing Wegener's granulomatosis.
Methodology
Multiplex flow immunoassay
Reference Interval
0.0–0.9
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 163067 | Anti-PR3 Antibodies | 46267-1 | 163068 | Anti-PR3 Antibodies | units | 46267-1 |
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