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For hours, walk-ins and appointments.Hepatitis A Virus (HAV) Antibody, Total With Reflex to IgM
CPT:
86708
Synonyms
- Anti-HAV
Special Instructions
If reflex test is performed, additional charges/CPT code(s) may apply.
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior ro the collection of a sample.
Expected Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum or EDTA plasma
Volume
2 mL
Minimum Volume
0.8 mL
Container
Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube, serum transfer tube, plasma transfer tube
Collection
If tube other than a gel-barrier tube is used, transfer separated serum/plasma to a labeled plastic transport tube. Do not freeze gel-barrier tube (pour off serum first).
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Heat-inactivated specimens; cord blood; cadaveric specimens; or body fluid other than serum or EDTA plasma; gross hemolysis; excessive lipmia; improper labeling
Test Details
Use
This test is used to aid in the diagnosis of active Hepatitis A (HAV) infection and differentiate between active and previous infection/vaccination.
HAV Antibody Testing Interpretation ChartHAV Total Antibody | HAV IgM | Comments |
|---|---|---|
Negative | Not done | No evidence of vaccination or previous infection; Susceptible to Hepatitis A infection |
Positive | Not done | Consistent with recent or remote Hepatitis A infection or antibody response to HAV vaccination |
Positive | Negative | Consistent with resolved Hepatitis A infection or antibody response to HAV vaccination |
Positive | Positive | Consistent with active Hepatitis A infection |
Limitations
This assay has not been FDA cleared or approved for the screening of blood or plasma donors. Assay performance characteristics have not been established for immunocompromised or immunosupressed patients, cord blood, or patients less than 2 years of age.
Methodology
Immunochemiluminometric assay (ICMA); (See individual tests for methodologies)
Additional Information
HAV is a picornavirus primarily transmitted via the fecal-oral route. HAV replicates in the liver and is shed in high concentrations in feces from 2-3 weeks before to 1 week after the onset of clinical illness. IgM antibody develops within a week of symptom onset, peaks around three months, and is usually no longer detectable after six months. Many cases of hepatitis A are subclinical, particularly in children. Antibody produced in response to HAV infection (anti-HAV) persists for life and confers protection against reinfection. The presence of IgM antibody to HAV is diagnostic of acute HAV infection. A positive test for total anti-HAV indicates immunity to HAV infection but does not differentiate current from previous HAV infection. Although usually not sensitive enough to detect the low level of protective antibody after vaccination, anti-HAV tests also might be positive after hepatitis A vaccination.
References
Miller JM, Binnicker MJ, Campbell S, et al. A guide to utilization of the microbiology laboratory for diagnisis of infectios diseases: 2018 update by the Infectious Disease Society of America and the American Society for Microbiology. Clin Infect Dis. 2018 Aug 31;67(6):813-816.30169655
Nelson NP, Weng MK, Hofmeister MG, et al. Prevention of Hepatitis A Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices, 2020. MMWR Recomm Rep. 2020 Jul 3;69(5):1-38.32614811
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 144226 | HAV Antibody w/ Rfx | 13951-9 | 006726 | Hep A Ab, Total | 13951-9 |
| Reflex Table for Hep A Ab, Total | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 006734 | Hep A Ab, IgM | 006734 | Hep A Ab, IgM | 13950-1 | |
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