AACR 2020 -- Informed selection of syngeneic models for use in preclinical drug development is critical for success. CT26 colorectal and 4T1-Luc breast tumors were treated with anti-mCTLA-4 to address how the tumor microenvironment influences therapeutic outcome.
AACR 2020 -- Hepatocellular carcinoma (HCC) is the third leading cause of cancer related deaths and is refractory to standard chemo and radiation therapies.
AACR 2020 -- The degree of methylation in the promoter region of the O-6-methylguanine-DNA methyltransferase (MGMT) gene is widely accepted as a prognostic biomarker of patient outcomes in Glioblastoma multiforme (GBM).
AACR 2020 -- The continual pressure to develop molecules that target the immune system requires that there are new, reliable and well-characterized preclinical models available.
AACR 2020 -- The complex and dynamic nature of the tumor-immune microenvironment (TME) presents challenges for identification of robust and predictive biomarkers in immuno-oncology (IO).
AACR 2020 -- Breast cancer is generally regarded as an immunologically "cold" cancer, often with minimal tumor CD8+ T cell infiltrate and low immunogenicity.
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