Rabies is a fatal disease, primarily found in canines, bats, foxes, raccoons and skunks worldwide. However, 99% of reported human cases are caused by canine transmission. In the wild, transmission primarily takes place through a bite wound of an infected animal via transfer of saliva. The rabies virus infects the central nervous system.

Leverage the needed testing solutions for your tobacco and various next-generation nicotine and tobacco products (NGPs), including heated tobacco products (HTPs), electronic nicotine delivery systems (ENDS) and modern oral products (MOPS).

SQA 2024 -- Establishing key performance indicators (KPI) for quality metrics and disseminating that information throughout an organization is crucial for a successful quality program. It is the key to continuous improvement. It is important to discern what metrics are valuable and the best way to communicate them effectively.

SQA 2024 -- Under the GLPs, it is a requirement that a QAU maintain a copy of a Master Schedule of all nonclinical laboratory studies conducted at the testing facility (21 CFR 58.35(b)(1) per the FDA.

SQA 2024 -- When it is time to write up an audit observation, it can be difficult to find the right words. There are dos and don'ts to writing audit findings. It is important to stay objective, state the facts and connect the finding to a regulation, standard or SOP. Also important is to know what to avoid when writing observations.

AACR 2024 -- Chimeric Antigen Receptor T (CAR-T) cell therapy has emerged as a promising approach for treating hematological malignancies, particularly B-cell acute lymphoblastic leukemia (B-ALL).

AACR 2024 -- Monoclonal antibodies (mAbs) that target tumor antigen have transformed cancer immunotherapy. Antibody-dependent cellular cytotoxicity (ADCC) is an indispensable therapeutic mechanism for mAbs, including antibody-drug conjugates, because they trigger immune-mediated antitumor activity in vivo.

AACR 2024 -- Immunotherapy aims to bolster the immune response within the tumor microenvironment (TME). However, checkpoint inhibitors utilized in the treatment of colon carcinoma have demonstrated efficacy only in certain patients.

AACR 2024 -- Traditional cancer cell lines used as surrogate models in vitro and in vivo have made significant contributions to cancer research and drug discovery.

AACR 2024 -- The failure of murine tumor models to adequately simulate the native biological milieu and tissue architecture of human malignancies, has fomented much discourse surrounding the exigencies of bench to bedside translation.