Kidney Stone Risk Panel
Also known as:Urine Calcium, Urine Oxalate, Urine Uric Acid, Urine Citric Acid (Citrate), Urine Creatinine, Renal Stone Risk Panel, Urine Supersaturation Profile
Formal name:Kidney Stone Risk Panel
Related tests:Kidney Stone Analysis, Calcium, Uric Acid, Creatinine, Chloride, Potassium, Sodium, Magnesium, Phosphorus, Complete Blood Count, Electrolytes, BUN, Urinalysis, Albumin, Microalbumin, PTH, Cystine
Why Get Tested?
To help evaluate a person's risk of developing a kidney stone; to help determine the underlying reason for a kidney stone; to help guide and monitor treatment
When to Get Tested?
When you have had two or more kidney stones and a health practitioner wants to evaluate your risk of developing additional kidney stones; when you have developed one kidney stone and are a child or have risk factors such as a family history of kidney stones, a single functional kidney, or a transplanted kidney
A 24-hour urine sample; frequently, two separate 24-hour urine samples are collected.
Test Preparation Needed?
How is it used?
A kidney stone risk panel is used to help evaluate the likelihood that an individual who has had two or more kidney stones will develop additional ones, indicating a recurrent problem.
Testing is sometimes used to evaluate risk after an initial occurrence of a stone if a person is considered to be at an especially elevated risk for forming more stones or for a person who is likely to develop kidney dysfunction if another kidney stone is formed.
This testing may be used to help guide and monitor the treatment of someone who has had a kidney stone.
Several other laboratory tests may also be used to help evaluate a person who has had a kidney stone, including:
- Individual 24-hour urine tests that may not be part of the kidney stone risk panel, such as cystine, sodium, potassium, chloride, or magnesium
- A urinalysis to evaluate urine constituents (substances, protein, red and white blood cells, pH, and presence of crystals or bacteria)
- Blood tests such as a blood urea nitrogen (BUN) and creatinine to evaluate kidney function, electrolytes (sodium, potassium, chloride, bicarbonate) and calcium to evaluate health status and compare to urine results
- A urine culture If a person shows signs of a urinary tract infection
- Kidney stone analysis is usually performed to evaluate the specific substances present in the stone, if the kidney stone is able to be collected.
When is it ordered?
A kidney stone risk panel is usually performed several weeks after a kidney stone has been resolved and is frequently run in duplicate on two different 24-hour urine sample collections to determine whether elevated levels of a substance are temporary or persistent.
In most cases, testing will be ordered when a person has had a second kidney stone develop, but it may be ordered after a first stone when a person is considered to be at an increased risk of stone formation or kidney dysfunction. This may include people who:
- Formed stones as a child
- Have a family history of kidney stones
- Had multiple kidney stones at the same time as their "initial" stone
- Have a single functional kidney, including those who have had a kidney transplant
Sometimes testing may be performed when a person has made changes to their lifestyle (such as recommended dietary changes or drinking more water) or medication changes in order to monitor the effectiveness of these changes.
What does the test result mean?
The results of the kidney stone risk panel are evaluated in conjunction with other tests performed in order to help determine a person's likely risk of developing another stone.
In general, if a substance, such as calcium or uric acid, is present in excess in both the blood and urine, then it represents an increased risk for kidney stone formation and a condition that should be further investigated to determine the cause.
Test results cannot predict, however, who will actually develop another kidney stone or when. Some people with mild elevations, or even results within normal ranges, may form stones, while other people with significantly increased results will not.
In a person who has made lifestyle or medication changes, decreasing levels represent a decreased risk of stone formation.
If a person is dehydrated, then the amount of urine produced in 24-hours (urine volume) will be low and the urine will be more concentrated. This can cause an excess of a substance per volume (dissolved in less liquid) and increase the likelihood of stone formation.
Kidney stone formation is also affected by urine pH (acidic/alkaline). Uric acid and cystine crystals can only form in acidic urine, while calcium phosphate and struvite stones form in alkaline urine. Struvite stones consist of magnesium ammonium phosphate and are associated with bacterial infections.
The table below summarizes what some test results may indicate:
|Test||Result Indicating Increased Kidney Stone Risk||Stone Formation / Comments|
|Creatinine||N/A||Blood and urine creatinine levels reflect kidney function; they may be used for comparing to other substances as the level of creatinine in blood is normally stable and, in urine, it reflects how dilute or concentrated the urine is.|
|Urine calcium||High||Possibility for calcium oxalate or calcium phosphate stones|
|Urine oxalate||High||Possibility for calcium oxalate stones|
|Urine uric acid||High||Uric acid stones may form; many who have increased uric acid also have gout|
|Urine citric acid||Low||Citric acid helps inhibit stone formation.|
Other less common tests are summarized below:
|Test||Result Indicating Increased Kidney Stone Risk||Stone Formation / Comments|
|Urine cystine||High||Associated with inherited condition causing excess cystine in urine; additional testing may be performed to further evaluate.|
|Urine phosphorus||High||Can contribute to calcium compound stone formation|
|Urine magnesium||Low||Helps inhibit stone formation|
|Urine sodium||High||Sodium can cause more calcium to be excreted into the urine, increasing the risk of calcium compound stones.|
Is there anything else I should know?
Kidney stones may be as small as a grain of sand, as large as a golf ball, or even larger, with some filling up the entire collecting system of the kidney. These are sometimes called "staghorn" calculi because the shape of the collecting system resembles the antlers of a deer. They can cause problems either because they grow large enough to obstruct urine flow or because they become dislodged or break off and begin to travel from a kidney through the ureter, where they can cause temporary obstruction and stretch, irritate, and/or damage the walls of the ureter. This movement can cause abrupt, extremely severe pain that may be intermittent or continuous.
Many stones will eventually pass out of the body in the urine, but some are too large or have too irregular a shape for the body to expel. With very large stones, which typically cannot pass from the kidney into the ureters, and for smaller stones that get into but do not pass through the ureters, some form of treatment is needed.
Not everyone who drinks too little liquid or who has an excess amount of substances in their urine will form kidney stones. Some stones will form in people for other reasons. Those who have had one kidney stone are at an increased risk for stone recurrence.
Abnormalities in the structure of the kidneys and/or urinary tract may cause the flow of urine to be impeded and crystals to be deposited, leading to formation of stones.
Struvite (magnesium ammonium phosphate) stones are associated with urinary tract infections.
What is being tested?
The kidney stone risk panel is a group of tests that measure the amounts of substances in urine that are commonly associated with kidney stone formation. In an individual who has already had kidney stones, an increased level of one of these substances can indicate both an elevated risk for developing additional stones and the likely type of stones that would form.
Kidney stone is a term for solid aggregates of minerals and salts that form in the kidneys. Typical kidney stones are composed of calcium oxalate, calcium phosphate, cystine, or uric acid.
These stones can form for several reasons, but the most common is because there is a high concentration of a particular substance or substances in the urine that precipitate and form crystals. The composition of the stone depends upon the substances present in excess. It may be all one compound or have different compounds in different layers. The majority of stones, about 75%, will contain calcium.
Kidney stone risk panels are intended to evaluate the risk of forming stones by testing for high concentrations of common stone-forming substances or low concentrations of stone-inhibiting substances. The specific tests included in a panel may vary somewhat from laboratory to laboratory but will typically include the following:
- Urine calcium
- Urine oxalate (oxalic acid)
- Urine uric acid
- Urine creatinine (does not cause stones but is used to tell if all urine was collected and help identify how concentrated the urine is)
- Urine citrate (citric acid; this substance helps inhibit the formation of stones)
Additional tests that may be part of some kidney stone risk panels and/or ordered separately include:
- Urine cystine
- Urine phosphorus
- Urine magnesium (helps inhibit stone formation)
- Urine sodium (does not directly cause stones but affects the amount of calcium in urine and thus its ability to form stones)
A high concentration of one or more of these substances in the urine can occur when a person produces and excretes an excess amount of the substance. Other contributing factors include chronically drinking an inadequate amount of fluids, becoming dehydrated to some degree, and having unusually concentrated urine.
For additional details, see the article on Kidney Stone Analysis.
How is the sample collected for testing?
A 24-hour urine collection is required for this test. Frequently, two different 24-hour urine samples are collected and tested to determine whether elevated levels of a substance are temporary or persistent.
NOTE: If undergoing medical tests makes you or someone you care for anxious, embarrassed, or even difficult to manage, you might consider reading one or more of the following articles: Coping with Test Pain, Discomfort, and Anxiety, Tips on Blood Testing, Tips to Help Children through Their Medical Tests, and Tips to Help the Elderly through Their Medical Tests.
Another article, Follow That Sample, provides a glimpse at the collection and processing of a blood sample and throat culture.
Is any test preparation needed to ensure the quality of the sample?
No test preparation is needed.
- Should everyone have a kidney stone risk panel performed?
No, the test is not indicated as a general screening test and is not intended for people who have never had a kidney stone.
- How can I prevent kidney stones?
One of the easiest things to do is to make sure that you stay hydrated by consistently drinking plenty of water. If you are at an increased risk of stones, then there may be other measures recommended by your health care provider.
- If I have had a kidney stone, should I avoid calcium?
You should work with your health care provider to determine the best treatment for you. If you had a stone with calcium in it, you may be instructed to decrease your intake a modest amount, but the clinical picture is often not as straight-forward as just consuming less of a substance. Some people absorb extra calcium from their food, but some excess calcium in the urine is related to an excess of sodium, so people who have had calcium-containing stones are often told to decrease salt intake rather than reducing calcium intake. Sometimes drastic reductions in calcium can worsen stone formation as well as affect bone health.
- Do I really need to save all of my urine for 24 hours?
Yes, your health care provider needs to know how much urine you are producing over a 24-hour period (volume) and how much of each of the substances is present. Since the substances may be eliminated in the urine at varying rates, the 24-hour urine is a better representation than a single or random urine sample and is a consistent frame of reference.
- Is it necessary to do both blood and urine tests?
That will depend on the information that your health care provider wants to evaluate. It is common to compare some substances in both the blood and the urine.
- Can stones form in other parts of the urinary tract besides the kidney?
Yes. For example, stones can form in the bladder; however, the reason for and the mechanism by which they form are different than for kidney stones. Instead of causes related to excreting excess amounts of a particular substance, bladder stones are typically caused by an inability to completely empty the bladder during urination. A bladder stone may be caused by some underlying urinary tract problem such as lack of bladder control, enlarged prostate, or urinary tract infection.
© 2017 American Association for Clinical Chemistry, republished from Lab Tests Online.*
Descriptions of clinical laboratory tests were originally prepared for use on Lab Tests Online, an award-winning patient education website on clinical laboratory testing. Lab Tests Online is produced by the American Association for Clinical Chemistry (AACC), a global scientific and medical professional organization dedicated to clinical laboratory science and its application to healthcare. The Lab Tests Online website is developed in collaboration with other laboratory professional societies and is funded in part through corporate sponsorships.