From initial screening through diagnosis and follow up, Labcorp supports the continuum of your patients’ care with:

  • Autoimmune epilepsy antibody testing
  • Genetic testing (NGS) panels
  • Genetic counselling services
  • Therapeutic drug level testing
  • Biochemical and metabolic testing

Genetic Testing (NGS) Panels

Approximately 70-80% of epilepsy cases are believed to be due to one or more genetic factors.2,3 Testing for epilepsy-related genes may be helpful for clarifying diagnosis and prognosis, selecting optimal treatments, and revealing information for family planning.4 Labcorp offers two genetic testing options: Clinical Epilepsy NGS Panel (630550): 46 genes, and Comprehensive Epilepsy NGS (630268): 811 genes.

Autoimmune Epilepsy Antibody Panel (505400)

This test provides an evaluation of possible autoantibodies in patients with suspected autoimmune epilepsy, and optimizes the likelihood of detecting neuronal specific autoantibodies. The test looks for the following antibodies: NMDA, LGI1, CASPR2, and GAD65.
 

 

Genetic Counseling Resources

Genetic counseling services are available to help patients understand their risk and results from NGS panels. Patients can schedule an appointment by calling 855-GC-CALLS or 855-422-2557.

Therapeutic drug level testing

Labcorp offers a broad catalog of tests for assessing epilepsy drug levels in patients.

Test No. 

Drug Name 

Test No. 

Drug Name 

007419 

Carbamazepine, Serum or Plasma 

716936 

Levetiracetam, Serum or Plasma 

716803 

Carbamazepine-10,11 Epoxide 

716928 

Oxcarbazepine, Serum or Plasma 

167129 

HLA B* 15:02, Carbamazepine Sensitivity 

007823 

Phenobarbital, Serum or Plasma 

702735 

Cenobamate (Xcopri), Plasma 

007401 

Phenytoin, Serum or Plasma 

007443 

Ethosuximide, Serum or Plasma 

809623 

Pregabalin, Urine 

716530 

Felbamate, Serum or Plasma 

007856 

Primidone, Serum or Plasma 

716811 

Gabapentin, Serum or Plasma 

716285 

Topiramate, Serum or Plasma 

007012 

Lacosamide 

007260 

Valproic Acid, Serum or Plasma 

716944 

Lamotrigine, Serum or Plasma 

007915 

Zonisamide, Serum or Plasma 

 

Biochemical and metabolic testing

Labcorp has a full suite of metabolic and biochemical genetic testing to help evaluate and monitor epilepsy patients, such as creatine, neopterin/tetrahydrobiopterin and neurotransmitter metabolites. Download our epilepsy brochure for a complete list.

References

  1. Epilepsy. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/epilepsy. June 20, 2019. Accessed 1/26/2021. 
  2. Hildebrand MS, Dahl HH, Damiano JA, et al. Recent advances in the molecular genetics of epilepsy. J Med Genet. 2013; 50:271–279.
  3. Myers CT, Mefford HC. Advancing epilepsy genetics in the genomic era. Genome Medicine. 2015;7:91.
  4. Poduri A, Sheidley BR, Shostak S, Ottman R. Genetic Testing in the Epilepsies-Developments and Dilemmas. Nat Rev Neurol. 2014 May;10(5):293-299. PubMed 24733164