HLA B*15:02, Carbamazepine Sensitivity

CPT: 81381
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  • B1502
  • Carbamazepine Sensitivity
  • HLA B*1502
  • HLA B1502

Special Instructions

If you have questions, please call 800-533-1037 (HLA customer service) for assistance in selecting the proper HLA test for the patient.

Expected Turnaround Time

3 - 7 days

Related Documents

Specimen Requirements


Whole blood or buccal swabs

Minimum Volume

7 mL whole blood or four buccal swabs


Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). When submitting buccal swabs, please use a buccal swab kit provided by LabCorp. To obtain the buccal kit, please telephone 800-533-1037.

Storage Instructions

Maintain whole blood at room temperature or refrigerate. Keep buccal swabs dry and at room temperature.

Causes for Rejection

Hemolysis; clotted specimen; insufficient volume of DNA

Test Details


This test has been recommended for patients of Asian descent who are being considered for carbamazepine therapy. The utility of this test for patients of other ethnic backgrounds has not been established.


Even with appropriate precautions, an occasional specimen may not be satisfactory for testing. In such cases, an additional specimen should be collected for retesting.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).


Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution.


Alfirevic A, Jorgensen AL, Williamson PR, Chadwick DW, Park BK, Pirmohamed M.. HLA-B locus in Caucasian patients with carbamazepine hypersensitivity. Pharmacogenomics J. 2006 Sep; 7(6):813-818.
Chung WH, Hung SI, Hong HS, et al. Medical genetics: A marker for Stevens-Johnson syndrome. Nature. 2004 Apr 1; 428(6982):486.
Hung SI, Chung WH, Jee SH, et al. Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr; 16(4):297-306.
Lonjou C, Thomas L, Borot N, et al. A marker for Stevens-Johnson syndrome: Ethnicity matters. Pharmacogenomics J. 2006 Jul-Aug; 6(4):265-268.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
167129 HLA-B*15:02 019422 HLA-B 57979-7
167129 HLA-B*15:02 019423 HLA-B 57979-7
167129 HLA-B*15:02 167384 HLA Methodology 49549-9

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