M3 Checklist: Multi-Condition Mental Health Screening Tool

Mental illness is a common health issue that needs to be treated as seriously as physical illnesses. Nationally-recognized, peer-reviewed and clinically validated, M3 Checklist – now offered exclusively through LabCorp – compiles and evaluates a patient’s potential for mood and anxiety symptoms using a secure web-based tool.


According to the Substance Abuse and Mental Health Services Administration (SAMHSA), any mental illness (or AMI) is defined as “having (currently or at any time in the past year) a diagnosable mental, behavioral, or emotional disorder (excluding developmental and substance use disorders) of sufficient duration to meet diagnostic criteria specified within the DSM-IV, regardless of functional impairment1.”

Routinely evaluating mental health within a primary care setting is an effective way to identify these issues, leading to appropriate diagnoses and treatment. LabCorp is proud to offer an efficient, time saving, and comprehensive tool for screening and monitoring of these issues.

Nearly 44 million Americans, or 18.1% of all adults, have dealt with such a disorder in the past year1. Of those, less than half receive needed treatment2.

Now offered exclusively through LabCorp, the M3 Checklist is a 27-question assessment of mood and anxiety symptoms that can be indicative of four common mental health conditions: anxiety disorders, bipolar disorder, depression and post-traumatic stress disorder (PTSD). Nationally-recognized, peer-reviewed and clinically validated3, M3 Checklist compiles and evaluates a patient’s potential for mood and anxiety symptoms using a secure web-based tool. An optional assessment for risk of alcohol abuse, the AUDIT-C, is also available separately or in combination with the M3 Checklist. 

M3 Checklist was developed by M3 Information, and the assessment is made available through LabCorp, its exclusive US distributor. M3 Information was founded by mental health experts, academic researchers, clinicians, information technology and business people with a goal to re-engineer the detection of mental health conditions and streamline integration into primary care. 

Physicians order the M3 Checklist and the AUDIT-C through LabCorp the same way they currently order lab testing, such as through their electronic health record (EHR) system or the LabCorp Link portal. The patient will receive an email notifying them to take the assessment, which is accessed through a secure link in the email and typically takes less than five minutes to complete. The assessment, which can be taken on any web-enabled device including computers, phones and tablets, is then evaluated by M3 Information, and the results are delivered by LabCorp to the physician, who can then review the results with the patient.

Use of the M3 Checklist generates an easy-to-read report for physicians and patients and allows for longitudinal tracking of follow-up results within the EHR for those being treated for mental health conditions. Physicians can use these M3 Checklist results, the accompanying risk assessment and patient discussion to guide them in formulating a diagnosis and treatment plan. The M3 Checklist is not designed to diagnose illness on its own, and in cases where a final diagnosis is unclear, referral to a specialist is recommended.


M3 Checklist Benefits:
  • Integrates screening for depression, anxiety, bipolar disorder and PTSD concerns. 
  • Provides added detail to help determine severity and comorbid psychological problems, as suggested by the U.S. Preventive Services Task Force.4
  • Optional assessment for alcohol misuse available by using the AUDIT-C.
  • Secure, easy-to-use web- and mobile-friendly interface that takes patients mere minutes to complete.