Zinc, Urine

CPT: 82570; 84630
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Test Details


  • Zn, Urine

Test Includes

Creatinine, urine; zinc, urine; zinc:creatinine ratio; zinc, urine (24-hour)


Evaluate zinc exposure; evaluate low serum zinc levels; evaluate compliance in oral zinc therapy of Wilson disease.2 Low urine zinc levels in the presence of depressed serum zinc tends to confirm zinc deficiency.


Zinc deficiency is usually accompanied by decreased urine zinc excretion. Zinc deficiency, however, may be in part due to excess urine losses, especially in cirrhosis, hemolytic anemias, sickle cell disease, alcoholism, diabetes, or chronic renal diseases.


Inductively-coupled plasma/mass spectrometry (ICP/MS)

Reference Interval

Environmental exposure: 100−900 μg/g creatinine,1 150−1200 μg/24 hours

Additional Information

Zinc poisoning through inhalation of zinc oxide fumes or dust often produces symptoms of respiratory tract irritation, chest pain and cough, fatigue, headache, nausea, fever, and muscle pain.3 Zinc is utilized as an alloying agent in brass and other metals, as well as in metal plating. Zinc chloride is often produced in the chemical smoke generators that are employed in industry. Zinc chloride is also used in soldering fluxes and wood preservatives.

Specimen Requirements


Urine (24-hour or random)


5 mL

Minimum Volume

1.7 mL


Plastic urine container, no preservative


Optional protocol: Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Screw the lid on securely.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Clinical Information

Special Instructions

If 24-hour urine is submitted, then request form must state 24-hour collection volume. Do not use preservative. Preservatives used for routine analysis may contain mercuric oxide (ie, Stabilur), which interferes with all metal testing. If both urinalysis and metal testing are ordered, please submit a separate urine specimen (containing no additive) for the metal testing.


1. Lauwerys RR, Hoet P. Industrial Chemical Exposure: Guidelines for Biological Monitoring. 2nd ed. Boca Raton, Fla: Lewis Publishers;1993: 293.
2. Milanino R, Marrella M, Moretti U, et al. Oral zinc sulphate as primary therapeutic intervention in a child with Wilson disease. Eur J Pediatr. 1989 Jun; 148(7):654-655. 2744040
3. Baselt RC, Cravey RH. Disposition of Toxic Drugs and Chemicals in Man. 4th ed. Foster City, Calif: Chemical Toxicology Institute;1995.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
003434 Zinc, Urine 019349 Zinc, Urine (24 hr) ug/24 hr 5765-3
003434 Zinc, Urine 019398 Zinc, Urine ug/L 21610-1
003434 Zinc, Urine 019399 Zinc/Creat. Ratio ug/g creat 13473-4
003434 Zinc, Urine 723280 Creatinine(Crt),U g/L 2161-8

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