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- Zn, Urine
Creatinine, urine; zinc, urine; zinc:creatinine ratio; zinc, urine (24-hour)
Evaluate zinc exposure; evaluate low serum zinc levels; evaluate compliance in oral zinc therapy of Wilson disease.2 Low urine zinc levels in the presence of depressed serum zinc tends to confirm zinc deficiency.
Zinc deficiency is usually accompanied by decreased urine zinc excretion. Zinc deficiency, however, may be in part due to excess urine losses, especially in cirrhosis, hemolytic anemias, sickle cell disease, alcoholism, diabetes, or chronic renal diseases.
Inductively-coupled plasma/mass spectrometry (ICP/MS)
Environmental exposure: 100−900 μg/g creatinine,1 150−1200 μg/24 hours
Zinc poisoning through inhalation of zinc oxide fumes or dust often produces symptoms of respiratory tract irritation, chest pain and cough, fatigue, headache, nausea, fever, and muscle pain.3 Zinc is utilized as an alloying agent in brass and other metals, as well as in metal plating. Zinc chloride is often produced in the chemical smoke generators that are employed in industry. Zinc chloride is also used in soldering fluxes and wood preservatives.
Urine (24-hour or random)
Optional protocol: Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Screw the lid on securely.
Maintain specimen at room temperature.
If 24-hour urine is submitted, then request form must state 24-hour collection volume. Do not use preservative. Preservatives used for routine analysis may contain mercuric oxide (ie, Stabilur), which interferes with all metal testing. If both urinalysis and metal testing are ordered, please submit a separate urine specimen (containing no additive) for the metal testing.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|003434||Zinc, Urine||019398||Zinc, Urine||ug/L||21610-1|
|003434||Zinc, Urine||019399||Zinc/Creat. Ratio||ug/g creat||13473-4|
|003434||Zinc, Urine||019349||Zinc, Urine (24 hr)||ug/24 hr||5765-3|