Zinc, Serum or Plasma

CPT: 84630
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Expected Turnaround Time

2 - 4 days

Related Information

Related Documents

Specimen Requirements


Plasma (preferred) or serum


1 mL

Minimum Volume

0.4 mL


Royal blue-top (EDTA) tube or royal blue-top tube without EDTA


Separate serum from cells within 45 minutes of collection, and transfer to a certified metal-free transport tube (PeopleSoft N° 111166) for shipment to the laboratory. Plasma may be separated immediately and transferred to a certified metal-free plastic transport tube (PeopleSoft N° 111166) for shipment to the laboratory.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements



Room temperature

28 days


28 days


28 days

Freeze/thaw cycles

Stable x4

Causes for Rejection

Certified metal-free plastic transport tube not submitted; unspun royal blue-top tube from which the plasma or serum has not been removed; gel-barrier tube

Test Details


Monitor exposure to zinc; evaluate suspected nutritional inadequacy (especially in enteral or parental nutrition, critically ill or burn patients); cases of diabetes or delayed wound healing; growth retardation; follow therapy (for example, when higher intravenous zinc doses are used to balance excessive ongoing GI losses in long-term total parenteral nutrition); follow oral zinc therapy in Wilson's disease; confirm acrodermatitis enteropathica and follow therapy


Levels may be low in fever, sepsis, estrogen therapy, stress, or myocardial infarction, reflecting mobilization from serum to the liver by interleukin. Levels are usually low in uremia with normal tissue levels. Levels may be high in familial hyperzincemia without toxicity or high zinc stores.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Inductively coupled plasma/mass spectrometry (ICP/MS)

Reference Interval




0 to 2 m



3 to 4 m



5 to 10 m



≥11 m



Additional Information

Chronic oral zinc supplementation interferes with copper absorption and may precipitate copper deficiency. Albumin is the primary zinc binding protein: zinc levels should be interpreted with awareness of serum albumin level.


Alfrey AC. Essential trace elements. In Seldin DW, Giebisch G, eds. The Kidney: Physiology and Pathophysiology. 2nd ed. New York, NY: Raven Press Ltd;1992:2993-3003.
Ruz M, Cavan KR, Bettger WJ, et al. Development of a dietary model for the study of mild zinc deficiency in humans and evaluation of some biochemical and functional indices of zinc status. Am J Clin Nutr. 1991; 53(5):1295-1303.2021137


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
001800 Zinc, Plasma or Serum 5763-8 001800 Zinc, Plasma or Serum ug/dL 5763-8

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