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Rituximab and Anti-Rituximab Antibody
Rituximab Drug Concentration and Anti-Rituximab Antibody Levels
Therapeutic monitoring of rituximab and antidrug antibody development for individuals with non-Hodgkin's lymphoma (NHL), chronic lymphocytic leukemia (CLL), and rheumatoid arthritis. This test provides rituximab drug concentration as well as the level of anti-rituximab antibodies.
Failure of rituximab therapy may not always be due to the presence of anti-rituximab antibodies. Conversely, the absence of anti-rituximab antibodies does not guarantee positive response to treatment.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Electrochemiluminescence immunoassay (ECLIA); chemiluminescence immunoassay (CLIA)
Serum (preferred) or heparin plasma
1 mL (Note: This volume does not allow for repeat testing.)
Gel-barrier tube, red-top tube, or green-top (heparin) tube
Serum or plasma must be separated from cells within 45 minutes of venipuncture. Submit serum or plasma in a plastic transport tube. To avoid delays in turnaround time when requesting multiple test on frozen samples, please submit separate frozen specimens for each test requested.
Causes for Rejection
Gross hemolysis; gross lipemia; icteric specimen
This test includes Serial Monitoring.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|504355||RTA Conc+RTA Ab||504356||Rituximab Drug Concentration||ug/mL||82467-2|
|504355||RTA Conc+RTA Ab||504357||Anti-Rituximab Antibody Level||ng/mL||82466-4|
|Reflex Table for Anti-Rituximab Antibody Level|
|Order Code||Order Name||Result Code||Result Name||UofM||Result LOINC|
|Reflex 1||000000||Serial Monitoring||000000||Serial Monitoring||N/A|