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Infliximab and Anti-Infliximab Antibody, DoseASSURE™ IFX

CPT: 80230; 82397
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  • Anti-TNF-alpha Drug
  • DoseASSURE
  • IFD
  • Remicade

Test Includes

This test includes serial monitoring.

Expected Turnaround Time

5 - 10 days

Specimen Requirements




2 mL

Minimum Volume

1 mL (Note: This volume does not allow for repeat testing).


Red-top tube or gel-barrier tube


Serum must be separated from cells within 45 minutes of venipuncture. Send serum in a plastic transport tube. To avoid delays in turnaround time when requesting multiple test on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Frozen (preferred) or refrigerated

Stability Requirements



Room temperature

7 days


7 days


359 days

Freeze/thaw cycles

Stable x6

Test Details


Provides infliximab drug concentration levels as well as levels of anti-infliximab antibodies.

In the absence of anti-infliximab antibodies, the infliximab drug level typically reflects the total infliximab concentration in serum. In the presence of anti-infliximab antibodies, the infliximab drug level typically reflects the antibody-unbound fraction of infliximab concentration in serum. The presence of infliximab drug, even at concentrations well above target treatment levels (>50 ug/mL), does not interfere with the anti-infliximab antibody detection. This assay may be helpful for any patients on infliximab therapy for diseases such as Crohn's disease, inflammatory bowel disease, ulcerative colitis, rhematoid arthritis, or other autoimmune conditions. This test includes long-term serial monitoring of results.


Failure of infliximab therapy may not always be due to the presence of anti-infliximab antibodies. In addition, the absence of anti-infliximab antibodies does not guarantee positive response to treatment.


Electrochemiluminescence Immunoassay (ECLIA)


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
503870 Infliximab Drug + Antibody 503772 Infliximab Drug Level ug/mL 39803-2
503870 Infliximab Drug + Antibody 503773 Anti-Infliximab Antibody ng/mL 72623-2
Reflex Table for Anti-Infliximab Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 000000 Serial Monitoring 000000 Serial Monitoring n/a

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