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Multiple Myeloma (MM) Profile, FISH
- Monoclonal Gammopathy of Undetermined Significance (MGUS)
- Plasma Cell Leukemia
Fluorescence in situ hybridization (FISH) for multiple myeloma (MM), targeting 13q14, IGH/CCND1, TP53, FGFR1/IGH, cMAF/IGH, amplification of 1p/1q, on plasma enriched cells.
Diagnostic test for multiple myeloma. Plasma cell enrichment diagnosis increased as much as 50% to 100%. The FISH results on the enriched assay should not be used as a quantitative assay, since the abnormal cells do not represent the percentage of abnormal cells in the aspirate.
Molecular mutations below the resolution of FISH will not be detected. Will not detect regions not targeted by FISH probes.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary.
Fluorescence in situ hybridization (FISH) and plasma cell enrichment
1 to 3 mL bone marrow
1 mL bone marrow
Green-top (sodium heparin) tube with bone marrow aspirate
Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze. Sample must arrive in the laboratory within 72 hours of collection.
Maintain specimen at room temperature.
Causes for Rejection
Whole blood; broken Vacutainer®; specimen received at testing facility 72 hours after collection
Indicate pertinent clinical diagnosis and previous cytogenetics studies on the test request form. If insufficient plasma cells are available, the following probe priority will be followed: Previous abnormality, p53, FGFR3/IGH, MAF/IGH, 13q14, 1p/1q, CCND1/IGH, 7/9/15 aneuploidy probes. If a chromosome study (510999) is ordered concurrently and sample is not sufficient for both tests, FISH will be prioritized.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|510325||Multiple Myeloma FISH Panel||510768||Specimen Type||31208-2|
|510325||Multiple Myeloma FISH Panel||510695||Cells Counted||62361-1|
|510325||Multiple Myeloma FISH Panel||510696||Cells Analyzed||62360-3|
|510325||Multiple Myeloma FISH Panel||510769||FISH Result||62357-9|
|510325||Multiple Myeloma FISH Panel||510318||Interpretation||62365-2|
|510325||Multiple Myeloma FISH Panel||510319||Director Review:||48672-0|
|510325||Multiple Myeloma FISH Panel||512123||80563-0|