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Short-term and, in some cases, long-term β-mitogen culturing of specimens, chromosome preparation, and analysis of 20 metaphases; multiple karyotypes prepared, including all abnormal clones
Include tentative diagnosis/treatment on the test request form. This is necessary for proper culturing and result interpretation. If plasma-enriched Multiple Myeloma (MM) Profile, FISH  is ordered concurrently and sample is not sufficient for both tests, FISH will be prioritized. Please direct any questions regarding this test to customer service at 800-345-4363.
7 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Bone marrow, blood (>4% blasts required − see Collection), lymph node, spleen, bone core, or effusion
2 mL bone marrow, 3 mL peripheral blood, or 0.5 to 1 cm³ tissue biopsy
Bone marrow or peripheral blood in pediatric green-top (heparin) tube; lymph node, spleen, bone core, CSF, or effusion in lymph node transport bottle
The requirement of >4% blasts for blood does not apply to cases of CLL, hairy cell leukemia, and some cases of small-cell lymphocytic leukemia (SCLL) or lymphoma, which can be β-mitogen stimulated. Submit bone marrow or peripheral blood at room temperature using Leukemia/Lymphoma Specimen Transport Kit (supplied by LabCorp). Submit lymph node, spleen, or bone core at room temperature using Lymph Node Transport Kit (supplied by LabCorp). Effusions may be sent in small sterile containers. Specimens should arrive in the laboratory within 48 hours of collection. Indicate date and time of collection on the test request form.
Maintain specimen at room temperature.
Hemolysis; gross contamination; non-neoplastic cells; clotted specimen; frozen specimen; fixed specimen; improper or too much anticoagulant
Karyotyping, physical localization of copy number changes, and mapping of breakpoints involved in translocations.
In studies of myeloid malignancy (eg, MDS in blood), availability of immature blasts, excessive amounts of sodium heparin, or use of lithium heparin (or EDTA) will inhibit growth of cell culture.
Short-term cell culture; synchronization; chromosome harvest; G-banding; analysis (20 metaphases) and karyotyping; long-term β-mitogen cultures in some B-cell leukemias
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|510999||Chromosome, Leukemia/Lymphoma||510678||Specimen Type||31208-2|
|510999||Chromosome, Leukemia/Lymphoma||510679||Cells Counted||62361-1|
|510999||Chromosome, Leukemia/Lymphoma||510680||Cells Analyzed||62360-3|
|510999||Chromosome, Leukemia/Lymphoma||510681||Cells Karyotyped||55199-4|
|510999||Chromosome, Leukemia/Lymphoma||510682||GTG Band Resolution Achieved||62358-7|
|510999||Chromosome, Leukemia/Lymphoma||510683||Cytogenetic Result||62356-1|
|510999||Chromosome, Leukemia/Lymphoma||510993||Director Review:||48672-0|
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